Publication Date:
1988-02-19
Description:
In an in vitro system for the Drosophila melanogaster male accessory gland, it was found that 10(-9)M juvenile hormone III could accurately mimic the copulation-induced response of increased protein synthesis in glands from virgin flies. Stimulation by this hormone required calcium in the medium. Experiments with tumor-promoting phorbol esters indicated that activation of protein kinase C can also cause the glands to increase protein synthesis. Stimulation of protein synthesis by juvenile hormone did not occur in mutants deficient in kinase C activity. These results suggest a membrane-protein-mediated effect of juvenile hormone that involves calcium and kinase C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamamoto, K -- Chadarevian, A -- Pellegrini, M -- New York, N.Y. -- Science. 1988 Feb 19;239(4842):916-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Biology Section, University of Southern California, Los Angeles 90089.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3124270" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium/*physiology
;
Drosophila melanogaster/*metabolism
;
Enzyme Activation/drug effects
;
Genitalia, Male/drug effects/metabolism
;
Juvenile Hormones/genetics
;
Male
;
Membrane Proteins/metabolism
;
Mutation
;
Phorbol 12,13-Dibutyrate
;
Phorbol Esters/pharmacology
;
Protein Biosynthesis
;
Protein Kinase C/*metabolism
;
Sesquiterpenes/*pharmacology
;
Tetradecanoylphorbol Acetate/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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