Publication Date:
1980-05-30
Description:
A synthetic peptide, representing a portion of the 16K (16,000 dalton)-fragment sequence within the pro-adrenocorticotropin/endorphin precursor molecule, potentiates the steroidogenic action of the 1 to 24 portion of adrenocorticotropin [ACTH(1-24)] on the rat adrenal cortex. The peptide has 27 amino acid residues and consists of gamma-melanotropin with a carboxyl terminal extension. It affects both the inner and outer adrenocortical zones of hypophysectomized animals, as evidenced by a synergistic augmentation of corticosterone and aldosterone production, respectively. The peptide can be distinguished from adrenocorticotropin by its activation of cholesterol ester hydrolase and its failure to stimulate cholesterol side-chain cleavage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pedersen, R C -- Brownie, A C -- Ling, N -- New York, N.Y. -- Science. 1980 May 30;208(4447):1044-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246578" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenal Cortex/*drug effects/metabolism
;
Adrenal Cortex Hormones/*biosynthesis
;
Adrenocorticotropic Hormone/*pharmacology
;
Aldosterone/biosynthesis
;
Animals
;
Corticosterone/biosynthesis
;
Endorphins/pharmacology
;
Female
;
Melanocyte-Stimulating Hormones/*pharmacology
;
Molecular Weight
;
Peptide Fragments/*pharmacology
;
Protein Precursors/pharmacology
;
Rats
;
Sterol Esterase/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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