Publication Date:
2012-07-07
Description:
The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. With the use of conditional gene inactivation, we found that the majority of cerebellar GluA1/A4-type AMPARs are expressed in BG cells. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saab, Aiman S -- Neumeyer, Alexander -- Jahn, Hannah M -- Cupido, Alexander -- Simek, Antonia A M -- Boele, Henk-Jan -- Scheller, Anja -- Le Meur, Karim -- Gotz, Magdalena -- Monyer, Hannah -- Sprengel, Rolf -- Rubio, Maria E -- Deitmer, Joachim W -- De Zeeuw, Chris I -- Kirchhoff, Frank -- R01-DC006881/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):749-53. doi: 10.1126/science.1221140. Epub 2012 Jul 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Physiology, University of Saarland, Homburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22767895" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Astrocytes/*metabolism/ultrastructure
;
Cerebellar Cortex/*cytology/growth & development/physiology
;
Conditioning, Eyelid
;
Excitatory Postsynaptic Potentials
;
Locomotion
;
Mice
;
Mice, Knockout
;
*Motor Activity
;
Neurites/physiology/ultrastructure
;
Patch-Clamp Techniques
;
Psychomotor Performance
;
Purkinje Cells/cytology/physiology
;
Receptors, AMPA/*metabolism
;
Signal Transduction
;
Synapses/physiology/ultrastructure
;
Synaptic Transmission
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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