ISSN:
1572-901X
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract The hydrolysis kinetics of p-nitrophenyl acetate (NA) catalyzed by CuII, ZnII and CoII complexes of tris(2-benzimidazylmethyl)amine (NBT) have been studied. The hydrolysis rate is first-order in both metal(II) complex and NA. The second-order rate constants, kcat are 0.083, 0.241 and 0.285 mol−1Ls−1 (298 K, I = 0.10 molL−1 KNO3, 0.02 molL−1 tris buffer, 40% MeCN aqueous solution) for Zn–NBT, Co–NBT and Cu–NBT complexes, respectively. The result indicates that the hydrolytic metalloenzyme activity of different metal complexes increases with the electrophilicity of the metal ions and that the complexes, in this paper, constitute that most efficient hydrolytic metalloenzyme models reported to date. An increase in MeCN content in the solution greatly reduces the hydrolytic activity of the nucleophiles.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1006967503458
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