Publication Date:
2015-07-05
Description:
Article Charcot–Marie–Tooth (CMT) neuropathy is associated with dominant mutations in five tRNA synthetase genes. Niehues et al . use BONCAT and FUNCAT to monitor proteome dynamics in a Drosophila CMT model, and reveal that these mutations result in translational slowdown. Nature Communications doi: 10.1038/ncomms8520 Authors: Sven Niehues, Julia Bussmann, Georg Steffes, Ines Erdmann, Caroline Köhrer, Litao Sun, Marina Wagner, Kerstin Schäfer, Guangxia Wang, Sophia N. Koerdt, Morgane Stum, Uttam L. RajBhandary, Ulrich Thomas, Hermann Aberle, Robert W. Burgess, Xiang-Lei Yang, Daniela Dieterich, Erik Storkebaum
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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