ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Digitale Medien
    Digitale Medien
    Insulin regulation of heart function in aging fruit flies (2004)
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 1275-1281 
    Details
    ISSN: 1546-1718
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] Insulin-IGF receptor (InR) signaling has a conserved role in regulating lifespan, but little is known about the genetic control of declining organ function. Here, we describe progressive changes of heart function in aging fruit flies: from one to seven weeks of a fly's age, the resting heart rate ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/ng1476
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Sirtuin activators mimic caloric restriction and delay ageing in metazoans (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 430 (2004), S. 686-689 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nature02789
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body (2004)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 429 (2004), S. 562-566 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] In Drosophila melanogaster, ageing is slowed when insulin-like signalling is reduced: life expectancy is extended by more than 50% when the insulin-like receptor (InR) or its receptor substrate (chico) are mutated, or when insulin-producing cells are ablated. But we have yet to resolve when ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nature02549
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Chaperoning extended life (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 390 (1997), S. 30-30 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The capacity to moderate internal and external stress is arguably the central function regulating senescence in whole-animal ageing. During ageing, molecular chaperones such as heat-shock proteins are thought to combat stress-related senescent dysfunction. In transgenic Drosophila melanogaster, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/36237
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 5
    Digitale Medien
    Digitale Medien
    Reproductive cessation in female mammals (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 392 (1998), S. 807-811 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] In female mammals, fertility declines abruptly at an advanced age. The human menopause is one example, but reproductive cessation has also been documented in non-human primates, rodents, whales, dogs, rabbits, elephants and domestic livestock. The human menopause has been considered an ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/33910
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 6
    Digitale Medien
    Digitale Medien
    Altitudinal variation for senescence in Melanoplus grasshoppers (1997)
    Springer
    Oecologia 111 (1997), S. 357-364 
    Details
    ISSN: 1432-1939
    Schlagwort(e): Key words Senescence ; Mortality ; Altitudinal variation ; Body size ; Melanoplus sanguinipes/devastator
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We describe differences in senescence among populations of grasshoppers that occur along an altitudinal gradient in the Sierra Nevada, California. Experimental males from five populations of the Melanoplus sanguinipes/devastator sibling species complex were reared in each of two thermal culture conditions from eggs of field-caught females. In both culture conditions, we measured the survival of adult cohorts from each population. Differences in the physiological capacity to survive in a sheltered, common environment reveal genetic differences in underlying rates of senescence, providing maternal effects do not affect the rate of aging in offspring. At each temperature, mortality rates increased as a function of age, which indicates that senescence occurs under laboratory conditions. Within each culture condition, cohorts originating from low-elevation populations had greater survival than did cohorts from high elevations. Variation in body size along the altitudinal gradient did not account for the differences in survival. We suggest that high-elevation populations have evolved accelerated senescence as a direct or an indirect result of selection on reproductive schedules, which are potentially truncated by severe winter conditions at the elevated sites.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004420050246
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 7
    Digitale Medien
    Digitale Medien
    Clutch size in the swallowtail butterfly, Battus philenor: the role of host quality and egg load within and among seasonal flights in California (1991)
    Springer
    Behavioral ecology and sociobiology 28 (1991), S. 337-344 
    Details
    ISSN: 1432-0762
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Clutch size in the pipevine swallowtail of California (Battus philenor hirsuta) varies widely within and among two seasonal flights, early and late spring. Pilson and Rausher (1988) proposed that variation in clutch size in a Texan B. philenor population is due to assessment of host quality with subsequent adjustment of clutch size and to differences in motivational state. The assessment hypothesis and a nonexclusive alternative that clutch size is determined by mature egg load were tested for populations in Sacramento, California. Weak and sporadic correlations between host quality and clutch size were found, suggesting that host assessment with adjustment of clutch size is not a strong factor in this population. Clutch size was highly correlated to mature egg load in the early but not in the late spring flight. Yet, females from both flights had similar loads of mature eggs. It is proposed that females lay clutch sizes proportional to egg load, up to a maximum threshold. The threshold may be lowered in the late spring flight in response to changes in overall host quality or to increased egg predation, reducing both the mean clutch size and the correlation between clutch size and egg load. Potential mechanisms for the change in behavior among flights, based on changes in the threshold, are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00164383
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 8
    Digitale Medien
    Digitale Medien
    Genetic analysis of extended life span in Drosophila melanogaster II. Replication of the backcross test and molecular characterization of the N14 Locus (1998)
    Springer
    Genetica 104 (1998), S. 33-39 
    Details
    ISSN: 1573-6857
    Schlagwort(e): life span ; artificial selection ; quantitative trait locus ; polygenic characters
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We are interested in localizing chromosomal regions that extend life span in Drosophila. Using stocks artificially selected for long life by Luckinbill and his colleagues, we have identified marker loci that are highly divergent in allelic frequencies between replicated long-lived lines and controls (Curtsinger et al., 1998). Several of the most divergent loci have been found to be associated with effects on life span in segregating backcross populations. Here we report an independent replication of the backcross test for the N14 marker locus, previously reported to extend male life spans by 12 days. The life span effect successfully replicates in males. N14 accounts for 30% of the total selection response in males. Life span extension occurs by a decrease in age-specific mortality rates at all ages, and is not attributable to modification of the slope of the age-specific mortality curve. The effect in females is small or nonexistent. Sequencing of the N14 locus shows that it is non-coding and not obviously regulatory, suggesting that the phenotypic effect arises from linkage disequilibrium with another locus or loci that directly affect life span. N14 DNA hybridizes to 63F/64A on the left arm of chromosome 3. The location is consistent with previous whole-chromosome substitution studies, and suggests new candidate genes for life span extension in Drosophila, including ras2.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1003420625925
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 9
    Digitale Medien
    Digitale Medien
    Mutation and senescence: where genetics and demography meet (1998)
    Springer
    Genetica 102-103 (1998), S. 299-314 
    Details
    ISSN: 1573-6857
    Schlagwort(e): mutation accumulation ; senescence ; demography ; mortality
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Two evolutionary genetic models–mutation accumulation and antagonistic pleiotropy–have been proposed to explain the origin and maintenance of senescence. In this paper, we focus our attention on the mutation accumulation model. We re-examine previous evidence for mutation accumulation in light of new information from large-scale demographic experiments. After discussing evidence for the predictions that have been put forth from models of mutation accumulation, we discuss two critical issues at length. First, we discuss the possibility that classical fruit fly stock maintenance regimes may give rise to spurious results in selection studies of aging. Second, we consider evidence for the assumptions underlying evolutionary models of aging. These models assume that mutations act additively on age-specific survival rate, that there exist mutations whose effects are confined to late age-classes, and that all mutations have equal effects. Recent empirical evidence suggests that each of these three assumptions is unlikely to be true. On the basis of these results, we do not conclude that mutation accumulation is no longer a valid explanation for the evolution of aging. Rather, we suggest that we now need to begin developing more biologically realistic genetic models for the evolution of aging.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1017047212008
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 10
    facet.materialart.
    Unbekannt
    Insulin regulation of heart function in aging fruit flies (2004)
    Springer Nature
    Details
    Publikationsdatum: 2004-11-21
    Print ISSN: 1061-4036
    Digitale ISSN: 1546-1718
    Thema: Biologie , Medizin
    Publiziert von Springer Nature
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    AKTUELLE ARTIKEL
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...