Publication Date:
2017-11-15
Description:
Ru(II) compounds have been universally investigated due to their unique physical and chemical properties. In this paper, one new Ru(II) compound based on 2,2'-bipy and Hpmtz (2,2'-bipy = 2,2'-bipyridine, Hpmtz = 5-(2-pyrimidyl)-1H-tetrazole), namely [Ru(2,2'-bipy)2(pmtz)][PF6]·0.5H2O was prepared and characterized by elemental analysis, IR and single crystal X-ray diffraction. [Ru(2,2'-bipy)2(pmtz)][PF6]·0.5H2O shows a mononuclear structure and forms a three dimensional network by non-classic hydrogen bonds. The ability of generation of ROS (reactive oxygen species) makes it has a low phototoxicity IC50 (half-maximal inhibitory concentration) after Xenon lamp irradiation on Hela cells in vitro. The results demonstrate that [Ru(2,2'-bipy)2(pmtz)][PF6]·0.5H2O with high light toxicity, low dark toxicity and good bio-compatibility may be a potential candidate for photodynamic therapy.
Print ISSN:
0044-2313
Electronic ISSN:
1521-3749
Topics:
Chemistry and Pharmacology
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