ISSN:
1573-8744
Keywords:
phenylbutazone
;
chloramphenicol
;
oxyphenbutazone
;
phenylbutazone-chloramphenicol interaction
;
chloramphenicol inhibition
;
horses
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The effects of i.v. chloramphenicol sodium succinate on the pharmacokinetics of i.v. phenylbutazone in six healthy adult horses were investigated. Administration of chloramphenicol sodium succinate to mares reduced mean (±SD) phenylbutazone clearance from 0.600±0.222 to 0.339±0.123 ml/min per kg and increased mean (±SD) half life from 244 ± 59.8 to 371 ± 80.8 min and mean residence time from 333 ± 86.2 to 533 ± 124 min. The mean steady-state volume of distribution of phenylbutazone was unchanged, with mean (±SD) values of 187 ± 28.9 ml/kg in control animals and 170 ± 32.4 ml/kg after chloramphenicol sodium succinate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059330
Permalink