ISSN:
1420-9071
Keywords:
Vascular smooth muscle
;
nitroglycerin
;
cyclic GMP
;
relaxation
;
desensitization
;
phosphatidylinositol
;
inositol phosphates
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The purpose of this study was to investigate the hypothesis that nitroglycerin-induced desensitization of vascular smooth muscle is mediated through cyclic GMP-disinhibition of phosphatidylinositol hydrolysis. Norepinephrine-induced contraction and increased levels of inositol monophosphate, a measure of phosphatidylinositol hydrolysis, in rat aorta. Prior treatment with nitroglycerin inhibited both the norepinephrine-induced contraction and the elevated levels of inositol monophosphate to the same relative magnitude. The nitroglycerin-induced inhibition of contraction and inositol monophosphate formation were prevented in tissues desensitized with nitroglycerin. These results suggest that: 1) nitroglycerin may inhibit vascular smooth muscle contraction through cyclic GMP-inhibition of phosphatidylinositol hydrolysis and 2) desensitization to the relaxant effects of nitroglycerin may be due to disinhibition of the hydrolysis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01945566
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