ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract The herbicide dinoseb (DNB) was administered to pregnant CD rats during the organogenetic period (days 6–15 of gestation) by gastric intubation with the following methods: a) 2.5; 5; 10 or 15 mg/kg dissolved in corn oil and given once a day; b) 7.5 or 10 mg/kg in corn oil given twice a day; c) 15 mg/kg in 1N NaOH titrated to pH 7 with HC1 given once a day. These treatments induced maternal toxicity and embryotoxicity (reduced fetal weight and increased frequency of extra ribs) at the highest doses with no teratogenic effects. However, the administration of DNB in the diet resulted in a specific teratogenic effect (microphthalmia) at a dose level (200 ppm) which also induced maternal toxicity. These results leave open the question of the proper way of administration to be used in teratology studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01066404
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