Publication Date:
2014-12-06
Description:
Background: Chronic Lymphocytic Leukemia (CLL) has been related to an increased susceptibility to infections particularly in advanced stages. Evidence is accumulating of an immune impaired response at early stages that could affect prognosis. We evaluated the pattern of seroresponse to common infections in CLL Rai0 cases and in general population controls. Methods: A case-control study within the multicase-control study (MCC Spain) and the International Cancer Genome Consortium (ICGC) was designed. 204 CLL cases, 69.6% newly diagnosed and 30.4% prevalent, and 370 population controls matched by sex, age and recruitment area were analyzed. All subjects provided a blood sample and answered a personal interview. In addition to socio-demographic, behavioral and medical characteristics for cases and controls, data on CD38, ZAP70 and common CLL deletions were available for analysis. Seroreactivities against the antigens from JC polyomavirus (JCPyV; VP1), Merkel cell poliomavirus (MCPyV; VP1), herpes simplex 1 (HSV1; gB), Epstein-Barr virus (EBV;zebra, EBNA, EA-D and VCAp18) and cytomegalovirus (CMV; pp150, CM2, pp52, pp28 and pp65) were measured using bead-based multiplex serology technology. Multivariate logistic regression models were used to examine seroprevalence to different viral infections and seroreactivity intensity (in tertiles) in cases and controls. Generalised additive models were used to explore seroreactivity patterns. Results: Seropositivity was very high in both cases and controls and was significantly higher for all infections tested among controls: HSV1 92.0% cases vs. 94.4% controls; CMV 84,4% vs. 88,3%; EBV 97,5% vs. 98,9%; JCPyV 56.6% vs. 68.9% and MCV 81.4% vs. 83.4%. Among seropositive subjects, a statistically significant decrease in antibody response was observed among CLL cases compared to controls (HSV-1 p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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