Electronic Resource
Springer
Protoplasma
207 (1999), S. 141-146
ISSN:
1615-6102
Keywords:
Endoplasmic reticulum
;
Signal peptide peptidase
;
γ-Secretase
;
SREBP
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Transmembrane segment proteases comprise a novel class of proteases that cleave substrates within hydrophobic membrane-spanning segments. They cleave in parts of proteins that upon first glance should be protected by the hydrophobic environment of the lipid bilayer. At present, no such protease has been isolated and biochemically characterized. They are defined according to the appearance of the respective cleavage products. All trans-membrane segment proteases seem to participate in a regulated two-step proteolytic process that plays a central role in cellular regulation or is part of a protein degradation pathway.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01282993
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