Publication Date:
2006-08-05
Description:
Blood clots perform an essential mechanical task, yet the mechanical behavior of fibrin fibers, which form the structural framework of a clot, is largely unknown. By using combined atomic force-fluorescence microscopy, we determined the elastic limit and extensibility of individual fibers. Fibrin fibers can be strained 180% (2.8-fold extension) without sustaining permanent lengthening, and they can be strained up to 525% (average 330%) before rupturing. This is the largest extensibility observed for protein fibers. The data imply that fibrin monomers must be able to undergo sizeable, reversible structural changes and that deformations in clots can be accommodated by individual fiber stretching.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950267/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950267/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, W -- Jawerth, L M -- Sparks, E A -- Falvo, M R -- Hantgan, R R -- Superfine, R -- Lord, S T -- Guthold, M -- P41 EB002025/EB/NIBIB NIH HHS/ -- R01 HL31048/HL/NHLBI NIH HHS/ -- R41 CA10312/CA/NCI NIH HHS/ -- R41 CA103120/CA/NCI NIH HHS/ -- R41 CA103120-01/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2006 Aug 4;313(5787):634.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Wake Forest University, Winston-Salem, NC 27109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16888133" target="_blank"〉PubMed〈/a〉
Keywords:
Blood Coagulation
;
Elasticity
;
Factor XIII/chemistry
;
Fibrin/*chemistry
;
Microscopy, Atomic Force
;
Stress, Mechanical
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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