Publication Date:
2018-06-15
Description:
Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing, Published online: 14 June 2018; doi:10.1038/s41467-018-04768-7 CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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