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  • 1
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    Crustal deformation measured in Southern California (1997)
    In:  Eos, Trans., Am. Geophys. Un., Luxembourg, Inst. Electrical & Electronics Engineers, vol. 78, no. 43, pp. 477,482, pp. B06303, (ISSN: 1340-4202)
    Details
    Publication Date: 1997
    Keywords: Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Fault zone ; Global Positioning System ; Migration of earthquakes ; Plate tectonics ; Geodesy ; Earthquake precursor: deformation or strain
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    MAGIC-web: a platform for untargeted and targeted N-linked glycoprotein identification (2016)
    Oxford University Press
    Details
    Publication Date: 2016-07-06
    Description: MAGIC-web is the first web server, to the best of our knowledge, that performs both untargeted and targeted analyses of mass spectrometry-based glycoproteomics data for site-specific N-linked glycoprotein identification. The first two modules, MAGIC and MAGIC+, are designed for untargeted and targeted analysis, respectively. MAGIC is implemented with our previously proposed novel Y1-ion pattern matching method, which adequately detects Y1- and Y0-ion without prior information of proteins and glycans, and then generates in silico MS 2 spectra that serve as input to a database search engine (e.g. Mascot) to search against a large-scale protein sequence database. On top of that, the newly implemented MAGIC+ allows users to determine glycopeptide sequences using their own protein sequence file. The third module, Reports Integrator, provides the service of combining protein identification results from Mascot and glycan-related information from MAGIC-web to generate a complete site-specific protein-glycan summary report. The last module, Glycan Search, is designed for the users who are interested in finding possible glycan structures with specific numbers and types of monosaccharides. The results from MAGIC, MAGIC+ and Reports Integrator can be downloaded via provided links whereas the annotated spectra and glycan structures can be visualized in the browser. MAGIC-web is accessible from http://ms.iis.sinica.edu.tw/MAGIC-web/index.html .
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 3
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    Rad52 SUMOylation affects the efficiency of the DNA repair (2012)
    Oxford University Press
    Details
    Publication Date: 2012-04-24
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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    PAPER CURRENT
  • 4
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    Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis [Microbiology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-01-12
    Description: Varicella-zoster virus (VZV) is a human α-herpesvirus that causes varicella (chickenpox) during primary infection and zoster (shingles) upon reactivation. Like other viruses, VZV must subvert the intrinsic antiviral defenses of differentiated human cells to produce progeny virions. Accordingly, VZV inhibits the activation of the cellular transcription factors IFN regulatory factor 3 (IRF3) and signal transducers and activators of transcription 1 (STAT1), thereby downregulating antiviral factors, including IFNs. Conversely, in this study, we found that VZV triggers STAT3 phosphorylation in cells infected in vitro and in human skin xenografts in SCID mice in vivo and that STAT3 activation induces the anti-apoptotic protein survivin. Small-molecule inhibitors of STAT3 phosphorylation and survivin restrict VZV replication in vitro, and VZV infection of skin xenografts in vivo is markedly impaired by the administration of the phospho-STAT3 inhibitor S3I-201. STAT3 and survivin are required for malignant transformation caused by γ-herpesviruses, such as Kaposi's sarcoma virus. We show that STAT3 activation is also critical for VZV, a nononcogenic herpesvirus, via a survivin-dependent mechanism. Furthermore, STAT3 activation is critical for the life cycle of the virus because VZV skin infection is necessary for viral transmission and persistence in the human population. Therefore, we conclude that takeover of this major cell-signaling pathway is necessary, independent of cell transformation, for herpesvirus pathogenesis and that STAT3 activation and up-regulation of survivin is a common mechanism important for the pathogenesis of lytic as well as tumorigenic herpesviruses.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Determination of junction avidity of cytolytic T cell and target cell (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-12-12
    Description: A direct measurement of the avidity of the junction between a cytotoxic T lymphocyte and its target cell was achieved by using a biophysical approach. A micromanipulation technique was used to determine the force required to separate a cytotoxic T cell (human clone F1, with specificity for HLA-DRw6) from its specific target cell (JY: HLA-A2, -B7, -DR4, w6) prior to delivery of the lethal hit. The force required to separate the F1-JY pair is 1.5 X 10(4) dynes per square centimeter. This junction avidity for F1-JY pairs is 6 to 13 times greater than that for F1-F1 and JY-JY pairs; the F1-JY conjugate requires a stronger separating force and is more easily rejoined than the homologous cell pairs. This study provides an estimate of the avidity of cytotoxic T cells for their target cells and insights into the biophysical correlates of the molecular complexes formed in the interaction of cytotoxic T cells and their targets during the cytotoxic process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sung, K L -- Sung, L A -- Crimmins, M -- Burakoff, S J -- Chien, S -- CA-13429/CA/NCI NIH HHS/ -- P01 HL 16851/HL/NHLBI NIH HHS/ -- R23 CA-37955/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1986 Dec 12;234(4782):1405-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3491426" target="_blank"〉PubMed〈/a〉
    Keywords: *Cell Communication ; Cytotoxicity, Immunologic ; HLA-DR Antigens/immunology ; HLA-DR6 Antigen ; Humans ; Mathematics ; T-Lymphocytes, Cytotoxic/*cytology/immunology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    WARC-92: Setting the agenda for the future
    Amsterdam : Elsevier
    Telecommunications Policy 16 (1992), S. 624-634 
    Details
    ISSN: 0308-5961
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0308-5961(92)90057-V
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The effect of excision on O2 diffusion and metabolism in soybean nodules (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 83 (1991), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Nitrogen-fixing nodules of soybean [Glycine max (L.) Merr. cv. Maple Arrow inoculated with Bradyrhizobium japonicum USDA 16] were studied before and after excision from the root to determine the role the O2 regulation plays in the inhibition of nodule activity and the potential for using excised nodules nodules in studies of nodule metabolism. Relative nitrogenase (EC 1.7.99.2) activity (H2 evolution in N2:O2) and nodule respiration (CO2 evolution) were monitored first in intact nodulated roots and then in freshly excised nodules of the same plant to determine the time course of the decline in nodule metabolism. Folowing excision, nitrogenase activity and respiration declined rapidly in the first minute and then more gradually. After 40 min the rate of H2 evolution was only 14–28% of that in the intact plant. In some nodules activity declined steadily, and in others there was a partial recovery in activity ca 10 min after detachment. Infected cell O2 concentration (Oi), measured by a spectro-photometric technique, also declined after nodule detachment with a time course similar to the declines in nitrogenase activity and respiration. Following excision, Oi levels declined rapidly from ca 21 nM in attached nodules to 8–12 nM at 4–10 min after excision and then more gradually to 2–3 nM O2 at 30–40 min after excision. These results show that the nodules' permeability to gas diffusion continued to be regulated for up to 40 min after detachement. At 40 min after detachment, when excised nodules displayed steady-state rates of gas exchange, linear increases in pO2 from 20 to 100% at 4% min−1 resulted in recoveries of H2 and CO2 evolution, indicating that Oi limited nitrogenase activity durig this period, and that energy reserves were greatly in excess of the O2 available for respiration. When detached nodules were equilibrated for 12 h at 20, 30 and 50% O2, Oi values measured at supra-ambient pO2 were greater than those at 20% O2 and were linked with a more rapid decline in nitrogenase activity. Also, increases in external pO2 (Oc) failed to stimulate nodule metabolism, suggesting that the nodules' energy reserves were no longer greatly in excess of their respiratory demands. It was concluded that soybean nodules could provide useful material for steady-state studies of nodule metabolism between 40 and 240 min after detachment, but to attain metabolic rates equivalent to in vivo rates the nodules must be exposed to above-ambient pO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3054.1991.tb01283.x
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  • 8
    Electronic Resource
    Electronic Resource
    The Inverse Spectral Method for Colliding Gravitational Waves (1998)
    Springer
    Mathematical physics, analysis and geometry 1 (1998), S. 313-330 
    Details
    ISSN: 1572-9656
    Keywords: colliding gravitational waves ; Ernst equation ; boundary-value problem ; inverse spectral method ; Riemann–Hilbert problem ; Goursat problem ; Einstein equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract The problem of colliding gravitational waves gives rise to a Goursat problem in the triangular region 1 ≤ x 〈 y ≤ 1 for a certain 2 × 2 matrix valued nonlinear equation. This equation, which is a particular exact reduction of the vacuum Einstein equations, is integrable, i.e. it possesses a Lax pair formulation. Using the simultaneous spectral analysis of this Lax pair we study the above Goursat problem as well as its linearized version. It is shown that the linear problem reduces to a scalar Riemann–Hilbert problem, which can be solved in closed form, while the nonlinear problem reduces to a 2 × 2 matrix Riemann–Hilbert problem, which under certain conditions is solvable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009870125810
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  • 9
    Electronic Resource
    Electronic Resource
    The variation of solar proton energy spectra and size distribution with heliolongitude (1975)
    Springer
    Solar physics 41 (1975), S. 189-223 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A statistical study of the initial phases of 185 solar particle events has been carried out using the data from the Goddard cosmic ray experiments on IMPs IV and V. Special emphasis is placed on the identification of the associated solar flare. The parent flare can be determined for 68 % of the events. It appears probable that most of the unidentified increases occur on the non-visible disc of the Sun. The existence of a ‘preferred-connection’ longitude between 20°W and 80° W is established by examining the heliolongitude of all the flare associated events. While power law in differential kinetic energy appears to give the best representation it cannot be distinguished from exponential in rigidity over the limited range of 20–80 MeV. It is argued that for heliolongitudes λ ⊙ = 20–80°W, γ p ,the spectral index determined at the time of maximum particle intensity is representative of the source spectra. For these heliolongitudes γ p displays a surprisingly small range with magnitudes varying mainly between 2.0 and 3.1. At lower energies γ p is smaller. Previous electron measurements provide almost identical average values of the source spectra over similar energy ranges. These results are discussed briefly in terms of Fermi acceleration models. For flare events located further away from the nominal field line connecting the Earth and the Sun, γ p becomes progressively steeper. The lower energies (4–20 MeV) do not exhibit this behavior. It is argued that this spectral steepening at the higher energies is the result of energy-dependent escape during the coronal diffusion process. The size distribution can be represented by a power law of the form dN/dI=I -α where N is the number of events per unit intensity and I is the maximum particle intensity at a given energy (usually taken at 40 MeV) with α ≈ 1.15 ±0.1. The same value of a applies to both eastern and western hemisphere events. The event size, on the average, appears to decrease approximately two orders of magnitude for each 60° away from the preferred connection region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00152967
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  • 10
    Electronic Resource
    Electronic Resource
    Long-time decay of the solutions of the Davey—Stewartson II equations (1995)
    Springer
    Journal of nonlinear science 5 (1995), S. 433-452 
    Details
    ISSN: 1432-1467
    Keywords: Davey-Stewartson II ; long-time decay ; inverse scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary Using the method of inverse scattering, the sup-norms of the solutions of the Davey—Stewartson II equations are shown to decay in the order of 1/¦t¦ as ¦t¦ goes to infinity. In the focusing case this result is obtained for small initial data, whereas in the defocusing case it is obtained for general initial data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01212909
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