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  • 1
    Electronic Resource
    Electronic Resource
    THE MUTAGENIC EFFECT OF D2O ON BACTERIOPHAGE T4 (1960)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 84 (1960), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1960.tb39100.x
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  • 2
    Electronic Resource
    Electronic Resource
    Applications of Genetic Engineering to the Pharmaceutical Industry (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 413 (1983), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1983.tb47874.x
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of a β-Lactamase Preproinsulin Fusion Protein in Escherichia Coli (1984)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 2 (1984), S. 165-168 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The level of expression of a β-lactamase human preproinsulin fusion protein1 in Escherichia coli was increased by plasmid and host manipulations. The initial expression level (0.01% of total protein) was increased two- to three-fold by replacing the p-lactamase promoter with two strong ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0284-165
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  • 4
    Electronic Resource
    Electronic Resource
    Stimulation of RNA chain initiation by the N gene protein of bacteriophage λ (1974)
    Springer
    Molecular genetics and genomics 134 (1974), S. 359-366 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary RNA transcription from the early leftward operon of the bacteriophage λ was studied. Hybridization to the separated DNA strands of the wild type phage, and to a biotin transducing phage containing viral sequences of only the extreme right or promoter proximal segment of this operon, allowed measurement of the rate of RNA chain initiation with respect to the total amount of RNA transcribed from this operon. Procedures which reduced either the amount of N gene protein synthesized, or its activity, were seen to depress transcription from the promoter proximal region approximately as much as from the entire operon. The RNA made when transcription was depressed did not have a conspiciously lower molecular weight, and the DNA-polymerase-RNA complex contained a correspondingly reduced number of polymerase molecules. All these observations are consistent with, and suggest, that under these conditions the function of the protein specified by gene N is to increase the frequency of initiation of RNA chains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337470
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  • 5
    Electronic Resource
    Electronic Resource
    A phase I trial of intraperitoneal recombinant interleukin 2 in patients with ovarian carcinoma (1988)
    Springer
    Investigational new drugs 6 (1988), S. 179-188 
    Details
    ISSN: 1573-0646
    Keywords: intraperitoneal interleukin 2 ; ovarian carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Seven patients with refractory stage III ovarian carcinoma were treated with escalating doses of human recombinant interleukin 2 (rIL-2) administered via the intraperitoneal (IP) route in an attempt to establish a dose and schedule of rIL-2 suitable for prolonged outpatient IP administration. Three patients went on to receive outpatient maintenance treatment twice weekly for 2–3 months. Doses ranged from 105 to 5 × 107 U/m2. The dose found most suitable for twice weekly outpatient IP administration was 106 U/m2. Dose-limiting toxicities consisted of diarrhea resulting in hypovolemia (5 patients) fever and chills (4 patients), nausea and vomiting (1 patient), mental status changes (2 patients), and azotemia (1 patient). These side effects were not prevented by indomethacin. Significant hypotension was not observed. Pharmacokinetic studies revealed extremely high IP concentrations of IL-2 which persisted for more than 24 hours. After a dose of 106 U/m2, the IP concentrations ranged from 670 to 760 U/ml. In one patient in whom concurrent serum concentrations were determined, the IP concentrations were over 100-fold higher than serum levels. After a dose of 107 U/m2, the IP concentrations of IL-2 ranged from 8700 to 14000. Concurrent serum levels in one patient revealed IP concentrations over 500-fold higher than serum levels. There were no consistent changes in T cell surface and activation markers on mononuclear cells from peripheral blood in 3 patients tested. Natural killer cell (NK) activity in peripheral blood increased in the three patients in whom it was measured. Four of the 7 patients progressed on treatment; 3 patients remained stable. We conclude that 106 U/m2 of rIL-2 is well-tolerated when administered by the IP route and that concentrations of IL-2 well in excess of that required to enhance cell-mediated cytotoxicity in vitro persist in the IP fluid for at least 24 hours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175395
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  • 6
    Electronic Resource
    Electronic Resource
    Transfer distribution of the DNA of T4 phage over its progeny (1965)
    Springer
    Molecular genetics and genomics 96 (1965), S. 66-82 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The distribution of the DNA of bacteriophage T4 over progeny produced by an infection ofE. coli with32P-labeled, deuterated parent phages was ascertained by examining the density of the transferred DNA in intact progeny virus particles and in DNA molecules extracted from progeny or phage-infected cells. The following results were obtained: 1. Those progeny phage that contain the bulk of transferred parental32P derive approximately 10% of their DNA from the parent. This value is a weight average, but it can be estimated that most of the transferred parental32P appears in progeny whose DNA complement comprises no less than 7 and no more than 13% atoms of parental origin. 2. In control experiments involving non-deuterated T4 parent phage, the transferred parental DNA appears in phage particles that are less dense than the average progeny. This fact must be taken into account in the interpretation of transfer distribution experiments involving density labels. 3. After breakage of the progeny DNA molecule into small fragments less than 1% of its original size, all the transferred parental atoms are found to reside in fragments that contain 50% parental atoms. This result is consistent with the interpretation that these fragments are half parental — half newly synthesized hybrid DNA molecules generated by semi-conservative replication. 4. The fragmentation of the parental DNA molecule occurs early in the infective process, no later than the start of replication of the vegetative phage DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00897236
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  • 7
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXVIII. 3-Alkoxy-1H-isoindole  -  Synthesen und Eigenschaften (1988)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 121 (1988), S. 243-252 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Studies on the Chemistry of Isoindoles and Isoindolenines, XXVIII.  -  3-Alkoxy-1H-isoindoles, Syntheses and Properties3-Alkoxy-1H-isoindoles 1 bearing substituents at the carbocyclic moiety have been synthesized from substituted 2,3-dihydro-1H-isoindol-1-ones 4 by regiospecific O-alkylation to 5 with trialkyloxonium tetrafluoroborates or methyl trifluoromethanesulfonate and subsequent NH deprotonation. According to the spectroscopic properties the semicyclic alkyl imidates 1 exist exclusively in the benzenoid 1H structure; the tautomeric o-quinonoid 2H structure 2 cannot be detected by spectroscopic means.
    Notes: 3-Alkoxy-1H-isoindole 1 mit Substituenten am carbocyclischen Teil wurden aus substituierten 2,3-Dihydro-1H-isoindol-1-onen 4 durch regiospezifische O-Alkylierung mit Trialkyloxonium-tetrafluoroboraten oder Trifluormethansulfonsäure-methylester zu 5 und nachfolgende NH-Deprotonierung synthetisiert. Aufgrund der spektroskopischen Befunde existieren die semicyclischen Imidsäure-alkylester 1 ausschließlich in der benzoiden 1H-Form; die tautomere 2H-Form 2 mit o-chinoider Struktur ist spektroskopisch nicht nachweisbar.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19881210209
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  • 8
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    Flood runoff in relation to water vapor transport by atmospheric rivers over the western United States, 1949-2015 (2017)
    Wiley
    Details
    Publication Date: 2017-11-17
    Description: Atmospheric rivers (AR) have a significant role in generating floods across the western United States. We analyze daily streamflow for water years 1949 to 2015 from 5477 gages in relation to water vapor transport by ARs using a 6-hour chronology resolved to 2.5° latitude and longitude. The probability that an AR will generate 50 mm/day of runoff in a river on the Pacific Coast increases from 12% when daily mean water vapor transport, DVT , is greater than 300 kg m -1 s -1 to 54% when DVT 〉600 kg m -1 s -1 . Extreme runoff, represented by the 99 th quantile of daily values, doubles from 80 mm/day at DVT =300 kg m -1 s -1 to 160 mm/day at DVT =500 kg m -1 s -1 . Forecasts and predictions of water vapor transport by atmospheric rivers can support flood risk assessment and estimates of future flood frequencies and magnitude in the western United States.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 9
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    Immunogenicity of proteins administered to humans for therapeutic purposes (1989)
    Cell Press
    Details
    Publication Date: 1989-07-01
    Print ISSN: 0167-7799
    Electronic ISSN: 1879-3096
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Cell Press
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  • 10
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    Expression of a β-Lactamase Preproinsulin Fusion Protein in Escherichia Coli (1984)
    Springer Nature
    Details
    Publication Date: 1984-02-01
    Print ISSN: 0733-222X
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer Nature
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