ISSN:
1574-6968
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
A biotransformation mixture which contained codeine and washed cells of Pseudomonas putida M10 gave rise to a number of transformation products that are of clinical importance which included hydrocodone, dihydrocodeine and 14β-hydroxycodeine. Incubations with the same organism and codeinone gave rise to 14β-hydroxycodeinone and 14β-hydroxycodeine. Cell-free extracts and membrane fractions of P. putida M10 were shown to catalyse the 14β-hydroxylation of codeinone. In addition, the potent analgesic oxycodone was shown to be produced from 14β-hydroxycodeinone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1574-6968.1999.tb08836.x
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