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  • 1
    Publication Date: 2014-04-05
    Description: When mounted on the skin, modern sensors, circuits, radios, and power supply systems have the potential to provide clinical-quality health monitoring capabilities for continuous use, beyond the confines of traditional hospital or laboratory facilities. The most well-developed component technologies are, however, broadly available only in hard, planar formats. As a result, existing options in system design are unable to effectively accommodate integration with the soft, textured, curvilinear, and time-dynamic surfaces of the skin. Here, we describe experimental and theoretical approaches for using ideas in soft microfluidics, structured adhesive surfaces, and controlled mechanical buckling to achieve ultralow modulus, highly stretchable systems that incorporate assemblies of high-modulus, rigid, state-of-the-art functional elements. The outcome is a thin, conformable device technology that can softly laminate onto the surface of the skin to enable advanced, multifunctional operation for physiological monitoring in a wireless mode.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Sheng -- Zhang, Yihui -- Jia, Lin -- Mathewson, Kyle E -- Jang, Kyung-In -- Kim, Jeonghyun -- Fu, Haoran -- Huang, Xian -- Chava, Pranav -- Wang, Renhan -- Bhole, Sanat -- Wang, Lizhe -- Na, Yoon Joo -- Guan, Yue -- Flavin, Matthew -- Han, Zheshen -- Huang, Yonggang -- Rogers, John A -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):70-4. doi: 10.1126/science.1250169.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700852" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Elasticity ; Electrocardiography/instrumentation/methods ; Electrocardiography, Ambulatory/instrumentation/methods ; Electroencephalography/instrumentation/methods ; Electromyography/instrumentation/methods ; Electrooculography ; Equipment Design ; Humans ; Male ; Microfluidics/*instrumentation ; Monitoring, Ambulatory/*instrumentation/methods ; Monitoring, Physiologic/*instrumentation/methods ; Remote Sensing Technology ; Silicone Elastomers ; *Skin ; Wireless Technology ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2015-01-13
    Description: Complex three-dimensional (3D) structures in biology (e.g., cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life. Compelling opportunities exist for analogous 3D architectures in human-made devices, but design options are constrained by existing capabilities in materials growth and assembly. We report routes to previously inaccessible classes of 3D constructs in advanced materials, including device-grade silicon. The schemes involve geometric transformation of 2D micro/nanostructures into extended 3D layouts by compressive buckling. Demonstrations include experimental and theoretical studies of more than 40 representative geometries, from single and multiple helices, toroids, and conical spirals to structures that resemble spherical baskets, cuboid cages, starbursts, flowers, scaffolds, fences, and frameworks, each with single- and/or multiple-level configurations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Sheng -- Yan, Zheng -- Jang, Kyung-In -- Huang, Wen -- Fu, Haoran -- Kim, Jeonghyun -- Wei, Zijun -- Flavin, Matthew -- McCracken, Joselle -- Wang, Renhan -- Badea, Adina -- Liu, Yuhao -- Xiao, Dongqing -- Zhou, Guoyan -- Lee, Jungwoo -- Chung, Ha Uk -- Cheng, Huanyu -- Ren, Wen -- Banks, Anthony -- Li, Xiuling -- Paik, Ungyu -- Nuzzo, Ralph G -- Huang, Yonggang -- Zhang, Yihui -- Rogers, John A -- New York, N.Y. -- Science. 2015 Jan 9;347(6218):154-9. doi: 10.1126/science.1260960.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. ; Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. ; Department of Civil and Environmental Engineering and Department of Mechanical Engineering, Center for Engineering and Health, and Skin Disease Research Center, Northwestern University, Evanston, IL 60208, USA. Department of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, P.R. China. ; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Department of Materials Science and Engineering, Department of Energy Engineering, Hanyang University, Seoul 133-791, Republic of Korea. ; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. ; Department of Civil and Environmental Engineering and Department of Mechanical Engineering, Center for Engineering and Health, and Skin Disease Research Center, Northwestern University, Evanston, IL 60208, USA. Key Laboratory of Pressure Systems and Safety (MOE), School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, P.R. China. ; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Department of Civil and Environmental Engineering and Department of Mechanical Engineering, Center for Engineering and Health, and Skin Disease Research Center, Northwestern University, Evanston, IL 60208, USA. ; Department of Materials Science and Engineering, Department of Energy Engineering, Hanyang University, Seoul 133-791, Republic of Korea. ; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. ; Department of Civil and Environmental Engineering and Department of Mechanical Engineering, Center for Engineering and Health, and Skin Disease Research Center, Northwestern University, Evanston, IL 60208, USA. jrogers@illinois.edu y-huang@northwestern.edu yihui.zhang2011@gmail.com. ; Department of Civil and Environmental Engineering and Department of Mechanical Engineering, Center for Engineering and Health, and Skin Disease Research Center, Northwestern University, Evanston, IL 60208, USA. Center for Mechanics and Materials, Tsinghua University, Beijing 100084, P.R. China. jrogers@illinois.edu y-huang@northwestern.edu yihui.zhang2011@gmail.com. ; Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. jrogers@illinois.edu y-huang@northwestern.edu yihui.zhang2011@gmail.com.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25574018" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2016-08-05
    Description: Recent advances in materials, mechanics, and electronic device design are rapidly establishing the foundations for health monitoring technologies that have "skin-like" properties, with options in chronic (weeks) integration with the epidermis. The resulting capabilities in physiological sensing greatly exceed those possible with conventional hard electronic systems, such as those found in wrist-mounted wearables, because of the intimate skin interface. However, most examples of such emerging classes of devices require batteries and/or hard-wired connections to enable operation. The work reported here introduces active optoelectronic systems that function without batteries and in an entirely wireless mode, with examples in thin, stretchable platforms designed for multiwavelength optical characterization of the skin. Magnetic inductive coupling and near-field communication (NFC) schemes deliver power to multicolored light-emitting diodes and extract digital data from integrated photodetectors in ways that are compatible with standard NFC-enabled platforms, such as smartphones and tablet computers. Examples in the monitoring of heart rate and temporal dynamics of arterial blood flow, in quantifying tissue oxygenation and ultraviolet dosimetry, and in performing four-color spectroscopic evaluation of the skin demonstrate the versatility of these concepts. The results have potential relevance in both hospital care and at-home diagnostics.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 4
    Publication Date: 2016-06-01
    Description: Power supply represents a critical challenge in the development of body-integrated electronic technologies. Although recent research establishes an impressive variety of options in energy storage (batteries and supercapacitors) and generation (triboelectric, piezoelectric, thermoelectric, and photovoltaic devices), the modest electrical performance and/or the absence of soft, biocompatible mechanical properties limit their...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 5
    Publication Date: 2016-11-19
    Description: Physiological mechano-acoustic signals, often with frequencies and intensities that are beyond those associated with the audible range, provide information of great clinical utility. Stethoscopes and digital accelerometers in conventional packages can capture some relevant data, but neither is suitable for use in a continuous, wearable mode, and both have shortcomings associated with mechanical transduction of signals through the skin. We report a soft, conformal class of device configured specifically for mechano-acoustic recording from the skin, capable of being used on nearly any part of the body, in forms that maximize detectable signals and allow for multimodal operation, such as electrophysiological recording. Experimental and computational studies highlight the key roles of low effective modulus and low areal mass density for effective operation in this type of measurement mode on the skin. Demonstrations involving seismocardiography and heart murmur detection in a series of cardiac patients illustrate utility in advanced clinical diagnostics. Monitoring of pump thrombosis in ventricular assist devices provides an example in characterization of mechanical implants. Speech recognition and human-machine interfaces represent additional demonstrated applications. These and other possibilities suggest broad-ranging uses for soft, skin-integrated digital technologies that can capture human body acoustics.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 6
    Publication Date: 2007-11-29
    Print ISSN: 0022-0744
    Electronic ISSN: 1477-9986
    Topics: Electrical Engineering, Measurement and Control Technology , Natural Sciences in General , Physics
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