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  • 1
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    On-Line Radical Scavenging Detection and Characterization of Antioxidants from Artemisia herba-alba (2012)
    Wiley
    Details
    Publication Date: 2012-04-12
    Description: Four caffeoylquinic acid (CQA) derivatives, 5- O -caffeoylquinic acid ( 1 ), 3,5-di- O -caffeoylquinic acid ( 3 ), 4,5-di- O -caffeoylquinic acid ( 4 ), and 3,4,5-tri- O -caffeoylquinic acid ( 5 ), have been isolated from Artemisia herba-alba growing wild in Algeria, using the on-line HPLC DAD DPPH radical-scavenging detection technique as guidance. In the course of the purification work, the non-frequent ( E )-2-( β - D -glucopyranosyloxy)-4-methoxycinnamic acid ( 2 ) has also been isolated. The CQAs showed fair-to-good antioxidant activities determined by the DPPH . scavenging assay. The structures of the five isolated compounds were determined by spectroscopic methods. The on-line HPLC DAD DPPH technique allowed for a rapid pinpointing of antioxidants in the studied plant, accomplishing the facile guided isolation of the target molecules. Algerian A. herba-alba could be an interesting source of natural antioxidants that deserve further work.
    Print ISSN: 0018-019X
    Electronic ISSN: 1522-2675
    Topics: Chemistry and Pharmacology
    Published by Wiley
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  • 2
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    On-Line Radical Scavenging Detection and Characterization of Antioxidants from Artemisia herba-alba (2012)
    Wiley
    Details
    Publication Date: 2012-04-15
    Description: Four caffeoylquinic acid (CQA) derivatives, 5- O -caffeoylquinic acid ( 1 ), 3,5-di- O -caffeoylquinic acid ( 3 ), 4,5-di- O -caffeoylquinic acid ( 4 ), and 3,4,5-tri- O -caffeoylquinic acid ( 5 ), have been isolated from Artemisia herba-alba growing wild in Algeria, using the on-line HPLC DAD DPPH radical-scavenging detection technique as guidance. In the course of the purification work, the non-frequent ( E )-2-( β - D -glucopyranosyloxy)-4-methoxycinnamic acid ( 2 ) has also been isolated. The CQAs showed fair-to-good antioxidant activities determined by the DPPH . scavenging assay. The structures of the five isolated compounds were determined by spectroscopic methods. The on-line HPLC DAD DPPH technique allowed for a rapid pinpointing of antioxidants in the studied plant, accomplishing the facile guided isolation of the target molecules. Algerian A. herba-alba could be an interesting source of natural antioxidants that deserve further work.
    Print ISSN: 0018-019X
    Electronic ISSN: 1522-2675
    Topics: Chemistry and Pharmacology
    Published by Wiley
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  • 3
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    Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse [Developmental Biology] (2018)
    National Academy of Sciences
    Details
    Publication Date: 2018-11-21
    Description: MicroRNA (miRNA)-124 is expressed in neurons, where it represses genes inhibitory for neuronal differentiation, including the RNA binding protein PTBP1. PTBP1 maintains nonneuronal splicing patterns of mRNAs that switch to neuronal isoforms upon neuronal differentiation. We find that primary (pri)-miR-124-1 is expressed in mouse embryonic stem cells where mature miR-124...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-11
    Description: To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated. The antral and pyloric gastric mucosa of mpS2-null mice was dysfunctional and exhibited severe hyperplasia and dysplasia. All homozygous mutant mice developed antropyloric adenoma, and 30 percent developed multifocal intraepithelial or intramucosal carcinomas. The small intestine was characterized by enlarged villi and an abnormal infiltrate of lymphoid cells. These results indicate that mpS2 is essential for normal differentiation of the antral and pyloric gastric mucosa and may function as a gastric-specific tumor suppressor gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lefebvre, O -- Chenard, M P -- Masson, R -- Linares, J -- Dierich, A -- LeMeur, M -- Wendling, C -- Tomasetto, C -- Chambon, P -- Rio, M C -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):259-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/Universite Louis Pasteur/College de France, Communaute Urbaine de Strasbourg, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8824193" target="_blank"〉PubMed〈/a〉
    Keywords: Adenoma/etiology/pathology ; Animals ; Base Sequence ; Cell Differentiation ; Cloning, Molecular ; Female ; Gastric Mucosa/cytology/*pathology ; Gene Targeting ; Genes, Tumor Suppressor ; Intestinal Mucosa/cytology/*pathology ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Neoplasm Proteins/genetics/*physiology ; Phenotype ; *Proteins ; Pyloric Antrum ; Stomach Neoplasms/*etiology/pathology ; Tumor Suppressor Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-03-05
    Description: As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity. Through integrated analysis of ITH and neoantigen burden, we demonstrate a relationship between clonal neoantigen burden and overall survival in primary lung adenocarcinomas. CD8(+)tumor-infiltrating lymphocytes reactive to clonal neoantigens were identified in early-stage non-small cell lung cancer and expressed high levels of PD-1. Sensitivity to PD-1 and CTLA-4 blockade in patients with advanced NSCLC and melanoma was enhanced in tumors enriched for clonal neoantigens. T cells recognizing clonal neoantigens were detectable in patients with durable clinical benefit. Cytotoxic chemotherapy-induced subclonal neoantigens, contributing to an increased mutational load, were enriched in certain poor responders. These data suggest that neoantigen heterogeneity may influence immune surveillance and support therapeutic developments targeting clonal neoantigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGranahan, Nicholas -- Furness, Andrew J S -- Rosenthal, Rachel -- Ramskov, Sofie -- Lyngaa, Rikke -- Saini, Sunil Kumar -- Jamal-Hanjani, Mariam -- Wilson, Gareth A -- Birkbak, Nicolai J -- Hiley, Crispin T -- Watkins, Thomas B K -- Shafi, Seema -- Murugaesu, Nirupa -- Mitter, Richard -- Akarca, Ayse U -- Linares, Joseph -- Marafioti, Teresa -- Henry, Jake Y -- Van Allen, Eliezer M -- Miao, Diana -- Schilling, Bastian -- Schadendorf, Dirk -- Garraway, Levi A -- Makarov, Vladimir -- Rizvi, Naiyer A -- Snyder, Alexandra -- Hellmann, Matthew D -- Merghoub, Taha -- Wolchok, Jedd D -- Shukla, Sachet A -- Wu, Catherine J -- Peggs, Karl S -- Chan, Timothy A -- Hadrup, Sine R -- Quezada, Sergio A -- Swanton, Charles -- 12100/Cancer Research UK/United Kingdom -- 1R01CA155010-02/CA/NCI NIH HHS/ -- 1R01CA182461-01/CA/NCI NIH HHS/ -- 1R01CA184922-01/CA/NCI NIH HHS/ -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2016 Mar 25;351(6280):1463-9. doi: 10.1126/science.aaf1490. Epub 2016 Mar 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Francis Crick Institute, London WC2A 3LY, UK. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London (UCL), London WC1E 6BT, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. ; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. Cancer Immunology Unit, UCL Cancer Institute, UCL, London WC1E 6BT, UK. ; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. ; Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark, 1970 Frederiksberg C, Denmark. ; The Francis Crick Institute, London WC2A 3LY, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. ; The Francis Crick Institute, London WC2A 3LY, UK. ; Cancer Immunology Unit, UCL Cancer Institute, UCL, London WC1E 6BT, UK. Department of Cellular Pathology, UCL, London WC1E 6BT, UK. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ; Department of Dermatology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany. German Cancer Consortium (DKTK), 69121 Heidelberg, Germany. ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; Hematology/Oncology Division, 177 Fort Washington Avenue, Columbia University, New York, NY 10032, USA. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Weill Cornell Medical College, New York, NY 10065, USA. Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Department of Internal Medicine, Brigham and Woman's Hospital, Boston, MA 02115, USA. ; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. Cancer Immunology Unit, UCL Cancer Institute, UCL, London WC1E 6BT, UK. s.quezada@ucl.ac.uk charles.swanton@crick.ac.uk. ; The Francis Crick Institute, London WC2A 3LY, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK. s.quezada@ucl.ac.uk charles.swanton@crick.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26940869" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/drug therapy/genetics/*immunology ; Aged ; Aged, 80 and over ; Antigens, Neoplasm/genetics/*immunology ; Antineoplastic Agents/therapeutic use ; CD4-Positive T-Lymphocytes/*immunology ; CTLA-4 Antigen/immunology ; Carcinoma, Non-Small-Cell Lung/genetics/immunology ; Cell Cycle Checkpoints/immunology ; Female ; Humans ; *Immunologic Surveillance ; Lung Neoplasms/drug therapy/genetics/*immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Melanoma/immunology ; Middle Aged ; Mutation ; Programmed Cell Death 1 Receptor/immunology ; Skin Neoplasms/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Optimal Fusion Filtering in Multisensor Stochastic Systems with Missing Measurements and Correlated Noises (2013)
    Hindawi
    Details
    Publication Date: 2013-05-28
    Description: The optimal least-squares linear estimation problem is addressed for a class of discrete-time multisensor linear stochastic systems with missing measurements and autocorrelated and cross-correlated noises. The stochastic uncertainties in the measurements coming from each sensor (missing measurements) are described by scalar random variables with arbitrary discrete probability distribution over the interval ; hence, at each single sensor the information might be partially missed and the different sensors may have different missing probabilities. The noise correlation assumptions considered are (i) the process noise and all the sensor noises are one-step autocorrelated; (ii) different sensor noises are one-step cross-correlated; and (iii) the process noise and each sensor noise are two-step cross-correlated. Under these assumptions and by an innovation approach, recursive algorithms for the optimal linear filter are derived by using the two basic estimation fusion structures; more specifically, both centralized and distributed fusion estimation algorithms are proposed. The accuracy of these estimators is measured by their error covariance matrices, which allow us to compare their performance in a numerical simulation example that illustrates the feasibility of the proposed filtering algorithms and shows a comparison with other existing filters.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 7
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    Covariance-Based Estimation from Multisensor Delayed Measurements with Random Parameter Matrices and Correlated Noises (2014)
    Hindawi
    Details
    Publication Date: 2014-06-17
    Description: The optimal least-squares linear estimation problem is addressed for a class of discrete-time multisensor linear stochastic systems subject to randomly delayed measurements with different delay rates. For each sensor, a different binary sequence is used to model the delay process. The measured outputs are perturbed by both random parameter matrices and one-step autocorrelated and cross correlated noises. Using an innovation approach, computationally simple recursive algorithms are obtained for the prediction, filtering, and smoothing problems, without requiring full knowledge of the state-space model generating the signal process, but only the information provided by the delay probabilities and the mean and covariance functions of the processes (signal, random parameter matrices, and noises) involved in the observation model. The accuracy of the estimators is measured by their error covariance matrices, which allow us to analyze the estimator performance in a numerical simulation example that illustrates the feasibility of the proposed algorithms.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 8
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    1H NMR-based method for the determination of complexation equilibrium parameters and chemical shifts in a hydrogen-bonded system with dynamic composition (2018)
    Wiley
    Details
    Publication Date: 2018-01-18
    Description: A photoswitchable self-complementary hydrogen bond system with an azoheteroaromatic backbone is presented. The trans -isomer ( T ) is the most stable form designed to dimerize through 6 hydrogen bond interactions. The dimerization constant ( K T · T ) and the dimer structure in the solid state have been obtained by conventional methods. When the cis -isomer ( C ) is generated through photoisomerization, the dynamics of the complex structures in solution change. The less stable cis -isomer can engage in dimerization, and a trans - cis complex may form with remaining trans -isomer (whose concentration increases as cis - trans thermal reversion takes place). A mathematical approach to calculate the trans - cis complexation constant ( K T · C ) along with an estimation of the cis -isomer dimerization constant ( K C · C ) from phenyl analogues allows a description of the species distribution in solution to be generated. A trans-cis photoswitchable azoheteroaromatic system that can form hydrogen-bonded homocomplex and heterocomplex when present as a mixture of the 2 isomers is characterized using 1 H NMR. The isomeric ratio changes because of thermal reversion to the more stable trans -isomer during the experiment, complicating the determination of the equilibrium parameters for the heterocomplex. We demonstrate how these parameters can be determined by fitting the data obtained as the composition of the system changes.
    Print ISSN: 0894-3230
    Electronic ISSN: 1099-1395
    Topics: Chemistry and Pharmacology , Physics
    Published by Wiley
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  • 9
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    Weathering evolution in lutites of the K/Pg transition red beds of the Tremp Group (Tremp-Isona Basin, south Pyrenees) (2017)
    Mineralogical Society of Great Britain and Ireland
    Details
    Publication Date: 2017-03-23
    Description: The Tremp–Isona basin (south-central Pyrenees, Lleida, Spain) shows maximum development of the Tremp Group (early Maastrichtian to late Paleocene) covering a wide geological record across the Cretaceous–Paleogene (K/Pg) boundary in continental facies. The mineralogy and geochemistry of lutites were used to assess the evolution of weathering from the Maastrichtian to the Eocene, and particularly for the red beds of the Lower Red and Upper Red Units (pre- and post-K/Pg, respectively). Chemical weathering decreased initially in the Maastrichtian (Gray Unit to Lower Red Unit), increasing subsequently from the Paleocene (Upper Red Unit) to Eocene units. ANOVA analysis of mineralogical compositions and cluster hierarchical analysis have been useful tools to select convenient lutites for assessment of weathering evolution by the chemical alteration index and by broadening of the 001 X-ray diffraction line of illite after ethylene glycol solvation. The lesser chemical weathering found in the Upper Red Unit (Danian) is interpreted in the context of relative warming and aridification, in climates of contrasting seasons and pronounced dry seasons.
    Print ISSN: 0009-8558
    Electronic ISSN: 1471-8030
    Topics: Geosciences
    Published by Mineralogical Society of Great Britain and Ireland
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  • 10
    Electronic Resource
    Electronic Resource
    A novel refractive index profile for optical characterization of nonlinear diffusion processes and planar waveguides in glass
    Amsterdam : Elsevier
    Optical Materials 3 (1994), S. 229-236 
    Details
    ISSN: 0925-3467
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0925-3467(94)90034-5
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    Paper (German National Licenses)
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