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  • 1
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    Evolutionary Recovery of a Recombinant Viral Genome (2012)
    Genetics Society of America (GSA)
    Details
    Publikationsdatum: 2012-07-03
    Beschreibung: It is well appreciated that the evolutionary divergence of genes and genomes from a common ancestor ultimately leads to incompatibilities if those genomes are hybridized. Far less is known about the ability and nature of compensatory evolution to yield the recovery of function in hybrid genomes. Here the major capsid gene of the bacteriophage T7 (40-kb dsDNA) was replaced with the homologous gene of either T3 or K11, each 22% different at the protein level from the T7 homolog. Initial fitness was moderately impaired for the T3 exchange, but the K11 exchange was not viable without a compensatory change in the T7 scaffolding protein. Subsequent adaptation of the transgenic phages led to nearly complete fitness recoveries. Compensatory changes were few, mostly in the transgene and its main interacting partner, the scaffolding protein gene. The large magnitude of fitness recovery with relatively few mutations suggests that the fitness costs of hybridizations and horizontal gene exchanges between moderately diverged genomes can potentially be short-lived through compensatory evolution.
    Digitale ISSN: 2160-1836
    Thema: Biologie
    Publiziert von Genetics Society of America (GSA)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Microbiology. A binding contract for anthrax (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-07-13
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, James J -- Parrish, Colin R -- New York, N.Y. -- Science. 2002 Jul 12;297(5579):201-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA. bull@bull.biosci.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12114612" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Anthrax/prevention & control/therapy ; Anthrax Vaccines/adverse effects/immunology ; Antibodies, Bacterial/genetics/*immunology/metabolism/therapeutic use ; Antibody Affinity ; Antigen-Antibody Complex/blood ; *Antigens, Bacterial ; Antitoxins/genetics/*immunology/metabolism/therapeutic use ; Bacillus anthracis/*immunology ; Bacterial Toxins/*immunology/metabolism/toxicity ; Bioterrorism ; Drug Industry ; Escherichia coli/genetics ; Genetic Engineering ; Humans ; Immunization, Passive ; Macrophages, Alveolar/metabolism ; Peptide Library ; Rats ; Receptors, Peptide/metabolism ; Recombinant Proteins
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Different trajectories of parallel evolution during viral adaptation (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1999-07-20
    Beschreibung: The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines under strong selection led to over a dozen nucleotide changes genomewide in each replicate. At least 96 percent of the amino acid substitutions appeared to be adaptive, and half the changes in one line also occurred in the other. However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wichman, H A -- Badgett, M R -- Scott, L A -- Boulianne, C M -- Bull, J J -- GM57755/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):422-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA. hwichman@uidaho.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10411508" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Adaptation, Physiological ; Amino Acid Substitution ; Bacteriophage phi X 174/*genetics/*physiology ; *Evolution, Molecular ; *Genome, Viral ; Genotype ; Mutation ; Salmonella typhimurium/*virology ; Selection, Genetic ; Sequence Deletion ; Temperature ; Viral Plaque Assay ; Viral Proteins/chemistry/genetics ; Virus Replication
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Sex determination: some like it hot (and some don't) (2008)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2008-02-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crews, David -- Bull, James J -- England -- Nature. 2008 Jan 31;451(7178):527-8. doi: 10.1038/451527a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18235487" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adaptation, Physiological/*physiology ; Animals ; Body Size ; Fadrozole/pharmacology ; Female ; Lizards/*embryology/*physiology ; Male ; Models, Biological ; Ovum/drug effects/growth & development ; Reproduction/physiology ; Sex Characteristics ; Sex Differentiation/*physiology ; *Temperature
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Evolution: Reptile sex determination goes wild (2015)
    Nature Publishing Group (NPG)
    Details
    Publikationsdatum: 2015-07-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, James J -- England -- Nature. 2015 Jul 2;523(7558):43-4. doi: 10.1038/523043a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cellular and Molecular Biology, the Center for Computational Biology and Bioinformatics and the Department of Integrative Biology, University of Texas at Austin, Austin, Texas 78712, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26135445" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Adaptation, Physiological ; Animals ; Female ; Male ; Sex Determination Processes/*physiology ; *Temperature
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von Nature Publishing Group (NPG)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Experimental phylogenetics: generation of a known phylogeny (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-01-31
    Beschreibung: Although methods of phylogenetic estimation are used routinely in comparative biology, direct tests of these methods are hampered by the lack of known phylogenies. Here a system based on serial propagation of bacteriophage T7 in the presence of a mutagen was used to create the first completely known phylogeny. Restriction-site maps of the terminal lineages were used to infer the evolutionary history of the experimental lines for comparison to the known history and actual ancestors. The five methods used to reconstruct branching pattern all predicted the correct topology but varied in their predictions of branch lengths; one method also predicts ancestral restriction maps and was found to be greater than 98 percent accurate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hillis, D M -- Bull, J J -- White, M E -- Badgett, M R -- Molineux, I J -- New York, N.Y. -- Science. 1992 Jan 31;255(5044):589-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Texas, Austin 78712.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1736360" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biological Evolution ; Chromosome Deletion ; DNA, Viral/*genetics ; Escherichia coli/genetics ; Genome, Viral ; *Phylogeny ; Restriction Mapping ; T-Phages/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    Of genes and genomes (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-10-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hillis, D M -- Bull, J J -- New York, N.Y. -- Science. 1991 Oct 25;254(5031):528.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Texas, Austin 78712.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948027" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Genes ; *Genome ; Mice ; Mice, Inbred Strains/*genetics ; *Phylogeny ; Polymorphism, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Selfish genes (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-04-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, J J -- Molineux, I J -- Werren, J H -- New York, N.Y. -- Science. 1992 Apr 3;256(5053):65.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Texas, Austin 78712.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1566058" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alleles ; Animals ; Biological Evolution ; Crosses, Genetic ; Drosophila/*genetics ; Female ; *Genes ; Heterozygote ; Male ; Mice
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    Evolution. Changing the cofactor diet of an enzyme (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2005-10-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ellington, Andrew D -- Bull, J J -- New York, N.Y. -- Science. 2005 Oct 21;310(5747):454-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departments of Chemistry and Integrative Biology, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. .ellington@mail.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16239467" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3-Isopropylmalate Dehydrogenase/*metabolism ; Amino Acid Substitution ; Catalysis ; *Evolution, Molecular ; Isocitrate Dehydrogenase/metabolism ; Leucine/biosynthesis ; Mutation ; NAD/*metabolism ; NADP/*metabolism ; Oxidation-Reduction ; Protein Engineering ; RNA/metabolism ; RNA, Catalytic/metabolism ; Selection, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    Parasites on the move (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1994-09-02
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, J J -- Levin, B R -- New York, N.Y. -- Science. 1994 Sep 2;265(5177):1469-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17833820" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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