Publication Date:
1998-05-09
Description:
Control of stability of beta-catenin is central in the wnt signaling pathway. Here, the protein conductin was found to form a complex with both beta-catenin and the tumor suppressor gene product adenomatous polyposis coli (APC). Conductin induced beta-catenin degradation, whereas mutants of conductin that were deficient in complex formation stabilized beta-catenin. Fragments of APC that contained a conductin-binding domain also blocked beta-catenin degradation. Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Behrens, J -- Jerchow, B A -- Wurtele, M -- Grimm, J -- Asbrand, C -- Wirtz, R -- Kuhl, M -- Wedlich, D -- Birchmeier, W -- New York, N.Y. -- Science. 1998 Apr 24;280(5363):596-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Delbruck Center for Molecular Medicine, Robert-Rossle-Strasse 10, 13122 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9554852" target="_blank"〉PubMed〈/a〉
Keywords:
Adenomatous Polyposis Coli Protein
;
Amino Acid Sequence
;
Animals
;
Axin Protein
;
Binding Sites
;
Body Patterning
;
Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
;
Cytoskeletal Proteins/chemistry/genetics/*metabolism
;
Glycogen Synthase Kinase 3
;
Humans
;
Mice
;
Molecular Sequence Data
;
Mutation
;
Phosphorylation
;
Proteins/chemistry
;
Proto-Oncogene Proteins/metabolism
;
*Repressor Proteins
;
Signal Transduction
;
*Trans-Activators
;
Tumor Cells, Cultured
;
Xenopus/embryology
;
Xenopus Proteins
;
beta Catenin
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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