Publication Date:
2015-03-11
Description:
Article The epigenetic factor Bmi1 regulates self-renewal of many adult stem cells, but its role in heart function is unknown. Here the authors show that Bmi1 prevents cardiac senescence by inhibiting the tumor suppressor protein p16 INK4a in adult mice, protecting them from dilated cardiomyopathy and heart failure. Nature Communications doi: 10.1038/ncomms7473 Authors: I. Gonzalez-Valdes, I. Hidalgo, A. Bujarrabal, E. Lara-Pezzi, L. Padron-Barthe, P. Garcia-Pavia, P. Gomez, J.M. Redondo, J.M. Ruiz-Cabello, L.J. Jimenez-Borreguero, J.A. Enriquez, J.L. de la Pompa, A. Hidalgo, S. Gonzalez
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
Permalink