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  • 1
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Measurements of energy weighted angular correlations in electron positron annihilations at c.m. energies of 22 GeV and 34 GeV are presented.
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  • 2
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Branching ratios for the decay τ→ν+(n pions) withn≧2 are presented. The new data include all possible charge configurations of the pion system and, in particular, final states containing one or several neutral pions. The data are compared with predictions from CVC (even number of pions in final state) and current algebra (odd number of pions). They strongly support the standard coupling of the τ to the weak charged current.
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  • 3
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The production of thef 0 in two photon collisions, with the subsequent decayf 0→π+π− has been observed in the CELLO detector at PETRA. Thef 0 peak was found to lie on a dipion continuum and to be shifted downwards in mass by ≃50 MeV/c2. The ππ mass spectrum from 0.8 to 1.5 GeV/c2 was well fitted by the model of Mennessier using only a unitarised Born amplitude and helicity 2f 0 amplitude. The previously observed mass shift and distortion of thef 0 peak are explained by strong interference between the Born andf 0 amplitudes. The only free parameter in the fit of the data to the model is the radiative widthΓ γγ(f 0). It was found that:Γ γγ(f 0)=2.5±0.1±0.5 keV where the first (second) quoted errors are statistical (systematic).
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 86 (1987), S. 479-483 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary ANP (atrial natriuretic peptide), a peptide found in granules of mammalian atrial cardiac myocytes, has been shown to be active in regulation of blood pressure and body water homeostasis. The existence of ANP in atrium, pituitary, adrenal gland, and kidney of the rat had been immunocytochemically demonstrated with an antibody against rat ANP (102–126). We used the same antibody in immunocytochemical studies for the detection of ANP in peripheral organs of the tree shrew (Tupaia belangeri). The antibody stained granules in myocytes of cardiac atria which indicated that it reacted with tree shrew ANP. In contrast to the rat, no immunoreactive cells were found in pituitaries and adrenal glands. However, in the kidneys distal tubules in outer medulla and cortex were labeled Ascending limbs of distal tubules were intensely stained when either the peroxidase-antiperoxidase (PAP) or the indirect immunofluorescence method were used. Collecting ducts and convoluted distal tubules in the outer cortex showed a granular type of staining when the immunofluorescence method was used. These data indicate that ANP is present in epithelial cells of distal tubules and collecting ducts, where it may be involved in the regulation of renal salt excretion.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 288 (1997), S. 1-10 
    ISSN: 1432-0878
    Keywords: Key words: Alpha2-adrenoceptor ; Beta-adrenoceptor ; 5HT1A receptor ; Stress ; Desensitisation ; Tree shrew ; Tupaia belangeri (Scandentia)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The prefrontal cortex has been reported to be involved in the regulation of emotional behaviour by integrating cognitive, emotional and autonomic information processes, and impairments of its functions are implicated in psychopathologies such as depression. Neuronal functioning in the prefrontal cortex is under the control of the noradrenergic and the serotonergic system which are both activated during stress. The present study aimed to quantify the effect of chronic psychosocial stress on alpha2-adrenoceptors, beta-adrenoceptors, and serotonin1A receptors in the prefrontal cortex. Male tree shrews (Tupaia belangeri) were subjected to subordination stress for 2, 10, 21 and 28 days, and binding sites for the alpha2-adrenergic antagonists 3H-rauwolscine and 3H-RX821002, for the beta-adrenergic antagonist 125I-iodocyanopindolol, and for the 5-hydroxytryptamine (5HT)1A receptor agonist 3H-8-hydroxy-2-(di-n-propylamino)tetralin were quantified by in vitro receptor autoradiography. Chronic psychosocial stress induced time-dependent receptor down- and upregulations. Beta-adrenoceptors were transiently reduced in numbers after just 2 days of psychosocial stress which is interpreted as agonist-mediated downregulation induced by high local concentrations of noradrenaline released from terminals originating from the locus coeruleus. Alpha2-adrenoceptors were transiently downregulated after 10 days, and upregulated after 28 days of psychosocial stress. These data indicate that the noradrenergic system adapts to the stress by counterbalancing its receptor numbers. 5HT1A receptors were only downregulated after 28 days of psychosocial stress, and thus react later than the noradrenergic receptors. In summary, our results show that monoaminergic receptors in the prefrontal cortex of tree shrews undergo dynamic changes during chronic psychosocial stress. These alterations probably have an impact on neuronal activity, and might contribute to the behavioural changes which have been previously described in subordinate male tree shrews.
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  • 6
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Multihadron events resulting frome + e − annihilation at the Υ-resonance are analysed with respect to lowest order QCD which predicts a dominant Υ decay into three vector gluons. Smearing effects due to the gluon fragmentation are so large, however, that no clear 3-jet structure or flatness is expected in the hadron final state. Instead, Monte Carlo simulations predict event structures with thrust and triplicity distributions distinctly different from those of two quark-jet and of phase space like decay mechanisms. The data are in perfect agreement with the 3-vector gluon decay as predicted by QCD and exclude dominantly phase space like or 2-quark jet decays. Also, the decay into scalar gluons is excluded by the data. An upper limit for the Υ-decay into one photon and two gluons is obtained.
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  • 7
    ISSN: 1573-6830
    Keywords: β-adrenoceptors ; down-regulation ; stress ; depression ; tree shrew
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. Stress is known to affect the functioning of the central noradrenergic system in a region-specific manner. The aim of the present investigation was to understand better the consequences of recurrent stressful experiences on central β-adrenoceptors. 2. Alterations in the central nervous β-adrenoceptor system resulting from different periods of psychosocial stress (PSS) were analyzed in male tree shrews (Tupaia belangeri) which were submitted to subordination stress for varying time periods. 3. In the first experiment, the whole number of β-adrenoceptors was analyzed in the forebrains of subordinate animals and controls by in vitro autoradiography using 125I-iodocyanopindolol (125ICYP), while nonspecific binding of the radioligand to serotonin receptors was blocked with 100 μM 5HT. 4. PSS affects β-adrenoceptors in a time-dependent manner. A decrease in receptor affinity occurred after just 21 days of PSS in cortical areas and in the hippocampus, indicating stress effects on the conformation of β-adrenoceptors. After 30 days of PSS,the numbers of β-adrenoceptors were significantly decreased in several cortical regions and in the olfactory area. 5. In the second experiment, we investigated the influence of PSS on both β1- and β2-adrenoceptors separately. 125ICYP binding was quantified in the presence of either ICI188.551 to block β2-adrenoceptors or in the presence of CGP20712A to block β1-adrenoceptors. 6. After 2, 10, 21,and 28 days of PSS, it become apparent that the two β-adrenoceptor subtypes are regulated independently. β1-Adrenoceptors were transiently down-regulated after 2 days of PSS in the prefrontal cortex and in the olfactory area and were decreased after 28 days of PSS in the parietal cortex and the hippocampus. A transient up-regulation of β1-adrenoceptors occurred in the pulvinar nucleus after 10 days of PSS. β2-Adrenoceptors were transiently down-regulated after 2 days of PSS in the prefrontal cortex and up-regulated in the pulvinar nucleus after 28 days of PSS. 7. These data demonstrate that chronic psychosocial stress in subordinate tree shrews leads to time-dependent changes in the central nervous β-adrenoceptors system. 8. The high regional variability in stress-induced β-adrenoceptor regulation is supposed to be due to the complex mechanisms of intracellular β-adrenoceptor sequestration, which includes down-regulation and/or reinsertion of receptors into the plasma membrane. These mechanisms may be important components of the regulatory apparatus which enables the individual to adapt to situations of recurrent stressful experiences by balancing the central nervous adrenoceptor number.
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  • 8
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The electronic width Γ ee and the muonic branching ratioB μμ =Γ μμ /Γtot of the Γ(9.46) have been measured as Γ ee =(1.33±0.14) andB μμ=(2.2±2.0)%. From these values a lower limit of Γtot〈23keV for the total width of the Γ(9.46) is obtained.
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  • 9
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Differential cross sections fore +e−→e +e−, τ+, τ- measured with the CELLO detector at $$\left\langle {\sqrt s } \right\rangle = 34.2GeV$$ have been analyzed for electroweak contributions. Vector and axial vector coupling constants were obtained in a simultaneous fit to the three differential cross sections assuming a universal weak interaction for the charged leptons. The results,v 2=−0.12±0.33 anda 2=1.22±0.47, are in good agreement with predictions from the standardSU(2)×U(1) model for $$\sin ^2 \theta _w = 0.228$$ . Combining this result with neutrino-electron scattering data gives a unique axial vector dominated solution for the leptonic weak couplings. Assuming the validity of the standard model, a value of $$\sin ^2 \theta _w = 0.21_{ - 0.09}^{ + 0.14}$$ is obtained for the electroweak mixing angle. Additional vector currents are not observed (C〈0.031 is obtained at the 95% C.L.).
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  • 10
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The production of prompt leptons at PETRA has been measured for c.m. energies of 14, 22 and 34 GeV. The rate of prompt electrons and muons is presented, including a determination of the semileptonic branching ratio of thec andb quarks. We obtain $$\begin{gathered} B(c \to \mu vX) = 12.3 \pm 2.9(stat) \pm 3.9(syst.){\raise0.5ex\hbox{$\scriptstyle 0$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle {0,}$}} \hfill \\ B(b \to \mu vX) = 8.8 \pm 3.4(stat) \pm 3.5(syst.){\raise0.5ex\hbox{$\scriptstyle 0$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle {0,}$}} \hfill \\ B(b \to evX) = 14.1 \pm 5.8(stat) \pm 3.0(syst.){\raise0.5ex\hbox{$\scriptstyle 0$}\kern-0.1em/\kern-0.15em\lower0.25ex\hbox{$\scriptstyle {0.}$}} \hfill \\ \end{gathered} $$ Systematic effects due to changes in fragmentation and other model parameters have been studied.
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