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  • 1
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    Phylogenetic perspectives in innate immunity (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-05-21
    Description: The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffmann, J A -- Kafatos, F C -- Janeway, C A -- Ezekowitz, R A -- New York, N.Y. -- Science. 1999 May 21;284(5418):1313-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France. jhoff@ibmc.u-strasbg.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10334979" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Culicidae/immunology/microbiology ; Drosophila/immunology/microbiology ; Humans ; Immunity, Active ; *Immunity, Innate ; Infection/*immunology ; Insect Vectors/immunology/microbiology ; Mammals/immunology ; Models, Immunological ; Phagocytosis ; Phylogeny ; Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    From sequence to chromosome: the tip of the X chromosome of D. melanogaster (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-24
    Description: One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benos, P V -- Gatt, M K -- Ashburner, M -- Murphy, L -- Harris, D -- Barrell, B -- Ferraz, C -- Vidal, S -- Brun, C -- Demailles, J -- Cadieu, E -- Dreano, S -- Gloux, S -- Lelaure, V -- Mottier, S -- Galibert, F -- Borkova, D -- Minana, B -- Kafatos, F C -- Louis, C -- Siden-Kiamos, I -- Bolshakov, S -- Papagiannakis, G -- Spanos, L -- Cox, S -- Madueno, E -- de Pablos, B -- Modolell, J -- Peter, A -- Schottler, P -- Werner, M -- Mourkioti, F -- Beinert, N -- Dowe, G -- Schafer, U -- Jackle, H -- Bucheton, A -- Callister, D M -- Campbell, L A -- Darlamitsou, A -- Henderson, N S -- McMillan, P J -- Salles, C -- Tait, E A -- Valenti, P -- Saunder, R D -- Glover, D M -- New York, N.Y. -- Science. 2000 Mar 24;287(5461):2220-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Hall, Cambridge CB10 1SD, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10731137" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Banding ; Computational Biology ; Cosmids ; DNA Transposable Elements ; DNA, Satellite ; Drosophila melanogaster/*genetics ; Genes, Insect ; In Situ Hybridization ; Repetitive Sequences, Nucleic Acid ; Sequence Analysis, DNA ; X Chromosome/*genetics/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Policy forum: European policy. Interesting times--biology, European science, and EMBL (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kafatos, F C -- New York, N.Y. -- Science. 2000 Feb 25;287(5457):1401, 1403.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Molecular Biology Laboratory, Heidelberg, Germany. kafatos@embl-heidelberg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10722387" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics/organization & administration/trends ; Animals ; Budgets ; Computational Biology ; Europe ; European Union ; Genome ; Humans ; *Laboratories/economics/organization & administration/trends ; *Molecular Biology/trends ; Public Policy ; *Research
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Malaria control with genetically manipulated insect vectors (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-05
    Description: At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alphey, Luke -- Beard, C Ben -- Billingsley, Peter -- Coetzee, Maureen -- Crisanti, Andrea -- Curtis, Chris -- Eggleston, Paul -- Godfray, Charles -- Hemingway, Janet -- Jacobs-Lorena, Marcelo -- James, Anthony A -- Kafatos, Fotis C -- Mukwaya, Louis G -- Paton, Michael -- Powell, Jeffrey R -- Schneider, William -- Scott, Thomas W -- Sina, Barbara -- Sinden, Robert -- Sinkins, Steven -- Spielman, Andrew -- Toure, Yeya -- Collins, Frank H -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):119-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oxford University, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364786" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Animals, Genetically Modified ; Anopheles/*genetics/parasitology/physiology ; Clinical Trials as Topic ; Ecology ; Evaluation Studies as Topic ; Genes, Insect ; *Genetic Engineering ; Genetics, Population ; Humans ; Insect Vectors/*genetics/parasitology/physiology ; Malaria/*prevention & control/transmission ; *Pest Control, Biological ; Plasmodium/physiology ; Public Health ; Public Opinion ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-05
    Description: Comparison of the genomes and proteomes of the two diptera Anopheles gambiae and Drosophila melanogaster, which diverged about 250 million years ago, reveals considerable similarities. However, numerous differences are also observed; some of these must reflect the selection and subsequent adaptation associated with different ecologies and life strategies. Almost half of the genes in both genomes are interpreted as orthologs and show an average sequence identity of about 56%, which is slightly lower than that observed between the orthologs of the pufferfish and human (diverged about 450 million years ago). This indicates that these two insects diverged considerably faster than vertebrates. Aligned sequences reveal that orthologous genes have retained only half of their intron/exon structure, indicating that intron gains or losses have occurred at a rate of about one per gene per 125 million years. Chromosomal arms exhibit significant remnants of homology between the two species, although only 34% of the genes colocalize in small "microsyntenic" clusters, and major interarm transfers as well as intra-arm shuffling of gene order are detected.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zdobnov, Evgeny M -- von Mering, Christian -- Letunic, Ivica -- Torrents, David -- Suyama, Mikita -- Copley, Richard R -- Christophides, George K -- Thomasova, Dana -- Holt, Robert A -- Subramanian, G Mani -- Mueller, Hans-Michael -- Dimopoulos, George -- Law, John H -- Wells, Michael A -- Birney, Ewan -- Charlab, Rosane -- Halpern, Aaron L -- Kokoza, Elena -- Kraft, Cheryl L -- Lai, Zhongwu -- Lewis, Suzanna -- Louis, Christos -- Barillas-Mury, Carolina -- Nusskern, Deborah -- Rubin, Gerald M -- Salzberg, Steven L -- Sutton, Granger G -- Topalis, Pantelis -- Wides, Ron -- Wincker, Patrick -- Yandell, Mark -- Collins, Frank H -- Ribeiro, Jose -- Gelbart, William M -- Kafatos, Fotis C -- Bork, Peer -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):149-59.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364792" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/chemistry/*genetics/physiology ; Biological Evolution ; Chromosome Inversion ; Chromosomes/genetics ; Cluster Analysis ; Dosage Compensation, Genetic ; Drosophila Proteins/chemistry/genetics/physiology ; Drosophila melanogaster/chemistry/*genetics/physiology ; Exons ; Gene Order ; Genes, Insect ; *Genome ; Insect Proteins/chemistry/genetics/physiology ; Introns ; Physical Chromosome Mapping ; Protein Structure, Tertiary ; *Proteome ; Pseudogenes ; Sequence Homology, Nucleic Acid ; Species Specificity ; Synteny
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Quantitative trait loci for refractoriness of Anopheles gambiae to Plasmodium cynomolgi B (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-04-18
    Description: The severity of the malaria pandemic in the tropics is aggravated by the ongoing spread of parasite resistance to antimalarial drugs and mosquito resistance to insecticides. A strain of Anopheles gambiae, normally a major vector for human malaria in Africa, can encapsulate and kill the malaria parasites within a melanin-rich capsule in the mosquito midgut. Genetic mapping revealed one major and two minor quantitative trait loci (QTLs) for this encapsulation reaction. Understanding such antiparasite mechanisms in mosquitoes may lead to new strategies for malaria control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zheng, L -- Cornel, A J -- Wang, R -- Erfle, H -- Voss, H -- Ansorge, W -- Kafatos, F C -- Collins, F H -- New York, N.Y. -- Science. 1997 Apr 18;276(5311):425-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Disease Control and Prevention, 4770 Buford Hi.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9103203" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/*genetics/immunology/*parasitology ; Chromosome Mapping ; Crosses, Genetic ; Female ; *Genes, Insect ; Genotype ; Insect Vectors/*genetics/immunology/*parasitology ; Lod Score ; Male ; Melanins/physiology ; Microsatellite Repeats ; Phenotype ; Plasmodium cynomolgi/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Challenges for European biology (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kafatos, F C -- New York, N.Y. -- Science. 1998 May 29;280(5368):1327.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9634403" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics ; *Biological Science Disciplines/economics/trends ; Budgets ; Europe ; European Union ; *Molecular Biology/economics/trends ; *Research Support as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-09-25
    Description: Two major developmentally regulated isoforms of the Drosophila chorion transcription factor CF2 differ by an extra zinc finger within the DNA binding domain. The preferred DNA binding sites were determined and are distinguished by an internal duplication of TAT in the site recognized by the isoform with the extra finger. The results are consistent with modular interactions between zinc fingers and trinucleotides and also suggest rules for recognition of AT-rich DNA sites by zinc finger proteins. The results show how modular finger interactions with trinucleotides can be used, in conjunction with alternative splicing, to alter the binding specificity and increase the spectrum of sites recognized by a DNA binding domain. Thus, CF2 may potentially regulate distinct sets of target genes during development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gogos, J A -- Hsu, T -- Bolton, J -- Kafatos, F C -- New York, N.Y. -- Science. 1992 Sep 25;257(5078):1951-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1290524" target="_blank"〉PubMed〈/a〉
    Keywords: *Alternative Splicing ; Amino Acid Sequence ; Animals ; Base Sequence ; Binding Sites ; DNA-Binding Proteins/*metabolism ; *Drosophila Proteins ; Drosophila melanogaster/genetics ; Hydrogen Bonding ; Molecular Sequence Data ; Oligodeoxyribonucleotides/chemistry/metabolism ; Protein Binding ; *Regulatory Sequences, Nucleic Acid ; Structure-Activity Relationship ; Transcription Factors/*metabolism ; *Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Toward cloning and mapping the genome of Drosophila (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-10-11
    Description: An ultimate goal of Drosophila genetics is to identify and define the functions of all the genes in the organism. Traditional approaches based on the isolation of mutant genes have been extraordinary fruitful. Recent advances in the manipulation and analysis of large DNA fragments have made it possible to develop detailed molecular maps of the Drosophila genome as the initial steps in determining the complete DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Merriam, J -- Ashburner, M -- Hartl, D L -- Kafatos, F C -- New York, N.Y. -- Science. 1991 Oct 11;254(5029):221-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, Los Angeles 90024.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1925579" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; *Chromosome Mapping ; Chromosomes ; *Cloning, Molecular ; Drosophila melanogaster/*genetics ; Gene Rearrangement ; Genes ; *Genome ; Mutation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Mouse biology at Monterotondo (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kafatos, Fotis C -- New York, N.Y. -- Science. 2004 Nov 26;306(5701):1475.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15567837" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes ; Animals ; Europe ; *Genetic Research ; International Cooperation ; Italy ; Mice/*genetics ; Research Personnel
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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