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  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 109 (1998), S. 11101-11108 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We demonstrate that pairwise contact potentials alone cannot be used to predict the native fold of a protein. Ideally, one would hope that a universal energy function exists, for which the native folds of all proteins are the respective ground states. Here we pose a much more restricted question: Is it possible to find a set of contact parameters for which the energy of the native contact map of a single protein (crambin) is lower than that of all possible physically realizable decoy maps? The set of maps we used was derived by energy minimization (not by threading). We seek such a set of parameters by perceptron learning, a procedure which is guaranteed to find such a set if it exists. We found that it is impossible to fine-tune contact parameters that will assign all alternative conformations higher energy than that of the native map. This finding proves that there is no pairwise contact potential that can be used to fold any given protein. Inclusion of additional energy terms, such as hydrophobic (solvation), hydrogen bond, or multibody interactions may help to attain foldability within specific structural families. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 91 (1998), S. 807-814 
    ISSN: 1572-9613
    Keywords: Damage spreading ; cluster algorithms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Damage spreading for Ising cluster dynamics is investigated numerically by using random numbers in a way that conforms with the notion of submitting the two evolving replicas to the same thermal noise. Two damage spreading transitions are found; damage does not spread either at low or high temperatures. We determine some critical exponents at the high-temperature transition point, which seem consistent with directed percolation.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 98 (2000), S. 1149-1168 
    ISSN: 1572-9613
    Keywords: directed percolation ; nonequilibrium phase transitions ; sandpiles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A simple model for flowing sand on an inclined plane is introduced. The model is related to recent experiments by Douady and Daerr and reproduces some of the experimentally observed features. Avalanches of intermediate size appear to be compact, placing the critical behavior of the model into the universality class of compact directed percolation. On very large scales, however, the avalanches break up into several branches, leading to a crossover from compact to ordinary directed percolation. Thus, systems of flowing granular matter on an inclined plane could serve as a first physical realization of directed percolation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 58 (1990), S. 685-706 
    ISSN: 1572-9613
    Keywords: Domain growth kinetics ; Ising model ; six-vertex model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The time evolution of the Ising model that describes shrinking domains is studied. A singly connected domain of Ising spins, embedded in a sea of the opposite phase, develops atT=0 according to a dynamic rule that does not allow its perimeter to increase. At long enough times the domain disappears; we show that the average lifetime of such a domain is proportional to its area. We also consider theT=0 dynamics of a single infinite quadrant. The area of the quadrant decreases during the time evolution, and we show that the area lost grows linearly with time. We solve a first passage time problem as well. That is, we calculate the average time it takes for the area lost to reach a given value for the first time. Lastly, we map the infinite quadrant model onto a diffusion problem with exclusion in one dimension. This latter problem is mapped onto a critical six-vertex model.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 51 (1988), S. 743-775 
    ISSN: 1572-9613
    Keywords: Neural networks ; perceptron ; memory ; learning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract An overview of recent activity in the field of neural networks is presented. The long-range aim of this research is to understand how the brain works. First some of the problems are stated and terminology defined; then an attempt is made to explain why physicists are drawn to the field, and their main potential contribution. In particular, in recent years some interesting models have been introduced by physicists. A small subset of these models is described, with particular emphasis on those that are analytically soluble. Finally a brief review of the history and recent developments of single- and multilayer perceptrons is given, bringing the situation up to date regarding the central immediate problem of the field: search for a learning algorithm that has an associated convergence theorem.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 93 (1998), S. 501-510 
    ISSN: 1572-9613
    Keywords: Ostwald ripening ; scaling state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Ostwald ripening is the last stage of the evolution of a system with two coexisting phases. It is a relatively simple nonequilibrium phenomenon with several interesting features. For example, as the system coarsens it goes through a scaling state, one which looks the same (up to an overall length scale, which grows) at all times. The dynamics of the problem can be mapped, in two dimensions, onto an evolving Coulomb system. In this work we present a brief summary of a novel theoretical approach to this problem, based on an analytic derivation (using a mean-field approach) of an effective two-body interaction between droplets of the minority phase. The resulting interacting many-body dynamics is solved by a very efficient numerical algorithm, allowing us to follow the evolution of more than 106 droplets on a simple workstation. The results are in excellent agreement with recent experiments.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 88 (1997), S. 617-636 
    ISSN: 1572-9613
    Keywords: Damage spreading ; directed percolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present a general definition of damage spreading in a pair of models. Using this general framework, one can define damage spreading in an objective manner that does not depend on the particular dynamic procedure that is being used. The formalism can be used for any spin-model or cellular automaton, with sequential or parallel update rules. At this point we present its application to the Domany–Kinzel cellular automaton in one dimension, this being the simplest model in which damage spreading has been found and studied extensively. We show that the active phase of this model consists of three subphases characterized by different damage-spreading properties.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 1998-04-01
    Print ISSN: 1063-651X
    Electronic ISSN: 1095-3787
    Topics: Physics
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  • 10
    Publication Date: 1997-07-01
    Print ISSN: 1063-651X
    Electronic ISSN: 1095-3787
    Topics: Physics
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