Publication Date:
2000-09-19
Description:
Clinicians may soon be able to mount a multipronged attack against cholesterol, the artery-clogging lipid whose buildup in the body is a major contributor to heart attacks and other cardiovascular diseases. In work reported on page 1524, a team has pinpointed a biological master switch in mice that controls three pathways that work together to both rid the body of excess cholesterol and prevent its absorption from the intestine. The work suggests a new mechanism for reducing cholesterol, for example, with drugs that turn up the activity of the master switch, a protein known as the retinoid X receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferber, D -- New York, N.Y. -- Science. 2000 Sep 1;289(5484):1446-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10991725" target="_blank"〉PubMed〈/a〉
Keywords:
ATP Binding Cassette Transporter 1
;
ATP-Binding Cassette Transporters/*metabolism
;
Animals
;
Bile Acids and Salts
;
Biological Transport/drug effects
;
Cholesterol/*metabolism
;
Cholesterol, Dietary/administration & dosage
;
DNA-Binding Proteins/metabolism
;
Glycoproteins/*metabolism
;
Humans
;
Intestinal Absorption/drug effects
;
Intestines/drug effects/*metabolism
;
Liver/metabolism
;
Macrophages/metabolism
;
Mice
;
Orphan Nuclear Receptors
;
*Receptors, Cytoplasmic and Nuclear
;
Receptors, Retinoic Acid/*metabolism
;
Receptors, Thyroid Hormone/metabolism
;
Retinoid X Receptors
;
Transcription Factors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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