Publication Date:
1999-07-10
Description:
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grakoui, A -- Bromley, S K -- Sumen, C -- Davis, M M -- Shaw, A S -- Allen, P M -- Dustin, M L -- New York, N.Y. -- Science. 1999 Jul 9;285(5425):221-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Immunology and the Department of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10398592" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/immunology/metabolism
;
Antigens, CD4/immunology/metabolism
;
CHO Cells
;
Cell Movement
;
Cricetinae
;
Cytochrome c Group/immunology/metabolism
;
Fluorescence
;
Histocompatibility Antigens/immunology/*metabolism
;
Intercellular Adhesion Molecule-1/immunology/metabolism
;
Ligands
;
Lipid Bilayers
;
*Lymphocyte Activation
;
Mice
;
Mice, Transgenic
;
Microscopy, Interference
;
Models, Immunological
;
Peptides/immunology/metabolism
;
Receptors, Antigen, T-Cell/immunology/*metabolism
;
Signal Transduction
;
T-Lymphocytes/*immunology/metabolism
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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