Publication Date:
2014-12-13
Description:
Article The adult gastro-intestinal tract harbours stem cells that differ in their differentiation programme and in the gene repertoire that they express. Here the authors show that single adult Lgr5-positive stem cells require Cdx2 to maintain their intestinal identity and are converted into pyloric stem cells in the absence of this transcription factor. Nature Communications doi: 10.1038/ncomms6728 Authors: Salvatore Simmini, Monika Bialecka, Meritxell Huch, Lennart Kester, Marc van de Wetering, Toshiro Sato, Felix Beck, Alexander van Oudenaarden, Hans Clevers, Jacqueline Deschamps
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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