Publication Date:
2014-07-26
Description:
Article Loss of function of the kinase PINK1 is associated with familial early-onset Parkinson’s disease and impaired clearance of damaged mitochondria. Here the authors show that the resulting oxidative stress activates the hypoxia regulator HIF1α, resulting in increased glycolysis and cell proliferation. Nature Communications doi: 10.1038/ncomms5514 Authors: Raquel Requejo-Aguilar, Irene Lopez-Fabuel, Emilio Fernandez, Luis M. Martins, Angeles Almeida, Juan P. Bolaños
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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