ISSN:
1573-8353
Keywords:
sulfones of 7β-alkoxycarbonyloxy-substituted cephalosporanic acidstert-butyl esters
;
sulfones of 7α-chloro- and 7-alkylidene-substituted 3-alkoxycarbonyloxymethylcephalosporanic acidstert-butyl esters
;
elastase inhibitors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Sulfones of 7β-alkoxycarbonyloxy-substituted cephalosporanic acid tert-butyl esters were synthesized by reduction of 7-oxocephalosporanic acid tert-butyl ester, acylation of the intermediate 7β-hydroxycephalosporanate with 2,2,2-trichloroethyl chloroformate or di-tert-butyl pyrocarbonate, and oxidation of the sulfur atom. Sulfones of 7α-chloro- and 7-alkylidene-substituted 3-alkoxycarbonyloxymethylcephalosporanic acid tert-butyl esters were obtained by replacement of the bromine atom in tert-butyl 3-bromomethylcephalosporanates with hydroxy group and acylation of the latter with chlorocarbonic esters. The cytotoxic activity of the synthesized substances was studied in vitro and also their ability to inhibit elastase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02297686
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