Publikationsdatum:
2010-02-26
Beschreibung:
Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released in the brain, where they have fundamentally important roles in social behaviours. In humans, disruptions of these peptide systems have been linked to several neurobehavioural disorders, including Prader-Willi syndrome, affective disorders and obsessive-compulsive disorder, and polymorphisms of V1a vasopressin receptor have been linked to autism. Here we report that the rat olfactory bulb contains a large population of interneurons which express vasopressin, that blocking the actions of vasopressin in the olfactory bulb impairs the social recognition abilities of rats and that vasopressin agonists and antagonists can modulate the processing of information by olfactory bulb neurons. The findings indicate that social information is processed in part by a vasopressin system intrinsic to the olfactory system.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842245/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842245/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tobin, Vicky A -- Hashimoto, Hirofumi -- Wacker, Douglas W -- Takayanagi, Yuki -- Langnaese, Kristina -- Caquineau, Celine -- Noack, Julia -- Landgraf, Rainer -- Onaka, Tatsushi -- Leng, Gareth -- Meddle, Simone L -- Engelmann, Mario -- Ludwig, Mike -- BB/F019009/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- G0700176/Medical Research Council/United Kingdom -- Biotechnology and Biological Sciences Research Council/United Kingdom -- England -- Nature. 2010 Mar 18;464(7287):413-7. doi: 10.1038/nature08826. Epub 2010 Feb 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20182426" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Antidiuretic Hormone Receptor Antagonists
;
Interneurons/drug effects/metabolism
;
Olfactory Bulb/cytology/*metabolism
;
Rats
;
Rats, Sprague-Dawley
;
Rats, Wistar
;
Receptors, Vasopressin/metabolism
;
Recognition (Psychology)/drug effects/*physiology
;
*Social Behavior
;
Vasopressins/antagonists & inhibitors/*metabolism
Print ISSN:
0028-0836
Digitale ISSN:
1476-4687
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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