Publikationsdatum:
1979-01-05
Beschreibung:
Extracts of the cerebral cortes of genetically obese (ob/ob) mice with hyperphagia contain 0.05 +/- 0.02 microgram (mean +/- standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 +/- 0.01 microgram per gram for their nonobese littermates and 0.20 +/- 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Straus, E -- Yalow, R S -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):68-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758680" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Brain/*metabolism
;
Cholecystokinin/*metabolism
;
Mice
;
Mice, Obese/*metabolism
;
Satiation/physiology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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