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Mycotoxins and Mycotoxicoses (2022)

Singh, Karuna. ; Kumari, Ankita.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Microbiology. ; Fungi. ; Mycology. ; Toxicology. ; Food Microbiology. ; Microbial genetics. ; Medical microbiology. ; Microbiology. ; Fungi. ; Toxicology. ; Food Microbiology. ; Microbial Genetics. ; Medical Microbiology.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Historical Aspect -- Chapter 2: Overview -- Chapter 3: Traditional Mycotoxins and Their Health Implications -- Chapter 4: Emerging/Lesser Known Mycotoxins and Their Clinicopathological Effects -- Chapter 5: Mushroom toxins and health hazards associated with them -- Chapter 6: Mycotoxins Co-occurrence Poisoning -- Chapter 7: Masked and New Mycotoxins -- Chapter 8: Extraction, characterization and analysis of Mycotoxins -- Chapter 9: Management Strategies -- Chapter 10: Mycotoxicokinetics and mycotoxicodynamics.

Kurzfassung: This book presents a comprehensive view on mycotoxins of agricultural as well as non-agricultural environments and their health effects in humans and animals. Mycotoxins have immunosuppressive effects; but some of them can cause cancers, mutagenicity, neurotoxicity, liver and kidney damage, birth defects, DNA damage and respiratory disorders. The problem of mycotoxins is long-lasting and their direct or indirect exposures to humans and animals must be further discussed. The first chapter will cover the historical perspective of mycotoxins along with timeline while the second one will provide overview including classification of mycotoxins and mycotoxicoses. The comprehensive information/ literature on traditional, emerging and mushroom mycotoxins will be given in chapters 3, 4 and 5 respectively. Chapter 6 will deal with mycotoxins co-occurrence poisoning whereas new and masked mycotoxins will be described in chapter 7. The important aspects of mycotoxin studies like extraction, characterization and analysis and management strategies will be summarized in 8 and 9 chapters. The last chapter of the book will cover the recent developments in toxicokinetic studies of mycotoxins. The book will have the most up-to-date information and recent discoveries to deliver accurate data and to illustrate essential points to a wide range of readers including mycologists, clinicians, agricultural scientists, chemists, veterinarians, environmentalists and food scientists.

Materialart: Online-Ressource

Seiten: XXIII, 182 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811923708

URL: https://doi.org/10.1007/978-981-19-2370-8

DOI: 10.1007/978-981-19-2370-8

DDC: 579

Sprache: Englisch

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Probiotic lactobacilli mediated changes in global epigenetic signatures of human intestinal epithelial cells during Escherichia coli challenge (2019)

Bhat, Mohd Iqbal ; Kumari, Ankita ; Kapila, Suman ; [weitere]

Springer

In: Annals of Microbiology. 2019; 69(6): 603-612. Published 2019 Feb 26. doi: 10.1007/s13213-019-01451-0.

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Publikationsdatum: 2019-02-26

Print ISSN: 1590-4261

Digitale ISSN: 1869-2044

Thema: Biologie

Publiziert von Springer

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Association of p53 codon 72 polymorphism and survival of North Indian lung cancer patients treated with platinum-based chemotherapy (2016)

Kumari, Ankita ; Bahl, Charu ; Singh, Navneet ; [weitere]

Springer

In: Molecular Biology Reports. 2016; 43(12): 1383-1394. Published 2016 Sep 10. doi: 10.1007/s11033-016-4072-1.

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Publikationsdatum: 2016-09-10

Print ISSN: 0301-4851

Digitale ISSN: 1573-4978

Thema: Biologie

Publiziert von Springer

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Assessment of Mortality and Its Associated Risk Factors in Patients with Transfusion Dependent Thalassemia in India (2019)

Dhanya, Rakesh ; Agarwal, Rajat Kumar ; Sedai, Amit ; [weitere]

American Society of Hematology

In: Blood. 2019; 134(Supplement_1): 973-973. Published 2019 Nov 13. doi: 10.1182/blood-2019-125151.

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Publikationsdatum: 2019-11-13

Beschreibung: Introduction: An assessment of morbidity and mortality caused by transfusion dependent thalassemia in India has never really been done despite thalassemia being the most prevalent life threatening non-communicable disorder of childhood. There is little structured understanding identifying the key risk factors feeding into research and policy making for effective management of thalassemia. With an estimated 10,000-12,000 children born with thalassemia each year in India, in addition to increasing focus on early pregnancy targeted screening, it seems critical to increase our understanding of risk factors associated with early mortality and morbidity. This is also relevant to family counselling about management options. Methodology: A retrospective analysis of mortality key risk factors in patients suffering from thalassemia major from 5 thalassemia day care centres in India was carried out. This included a total of 1,087 patients (656 males and 431 females with a median age of 8.6 years) enrolled for care between 1 Jan 2010 - 31 Oct 2018 at these centres. These centres were set up by a non-profit organization in collaboration with blood banks and /hospital facilities with the objective to provide comprehensive thalassemia care; A common web-based application was employed (ThalCare™). This system was used to track information associated with treatment including disease history at enrolment, demographic data and follow-up information. All analyses were performed with R Statistical software (3.5.2). Survival analysis was done from the age at presentation to the centre till October 2018. The reasons for mortality were categorized. Overall survival was also separately analyzed for patients in their 1st,2nd, 3rd or subsequent decades of life. The Cnaan and Ryan approach was used as patients entered and left the study cohort (left censored and right truncated data) and observation began only at enrolment and not at disease onset Results: The median age at enrolment was 5.4 years and the median follow up at the centre was 2.5 years. A total of 86 patients were cured by bone marrow transplantation (BMT), 13 of them moved to other centres for care and 41 patients died during the study period (28 males and 13 females). The median age at death was 15.4 years. Actuarial survival at 26.9 years of age was 50% (Figure 1) and under-five mortality was 7 times higher than the general population. Patients with transfusion-transmitted infections (TTI) had 3.4 times higher risk of death (p=0.031). Serum ferritin 〉4,000 ng/dL was associated with 4.6 times higher risk of mortality compared to ferritin 2 gm/dL/week had 7.7 times higher mortality risk compared to

Print ISSN: 0006-4971

Digitale ISSN: 1528-0020

Thema: Biologie , Medizin

Publiziert von American Society of Hematology

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Information and Communication Technology Applied to Continuing Quality Improvement for the Care and Cure of Childhood Severe Hematological Disorders in India (2019)

Agarwal, Rajat Kumar ; Dhanya, Rakesh ; Kumari, Ankita ; [weitere]

American Society of Hematology

In: Blood. 2019; 134(Supplement_1): 3468-3468. Published 2019 Nov 13. doi: 10.1182/blood-2019-125106.

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Publikationsdatum: 2019-11-13

Beschreibung: Introduction: Continued quality improvement systems are necessary not only to maintain minimum quality standards, but also contribute to improved outcomes (Snowden et al. 2017; Hashmi et al. 2017). In-spite of its importance, the implementation of a functional Quality Management System (QMS) in the routine daily activity oh health professionals may be a challenge, especially in resource limited settings (Hashmi et al. 2017). Methodology: BMTPlus is an information and communication technology (Agarwal et al. 2014) platform that has been used for knowledge management by Sankalp-People Tree Centre for Paediatric BMT, Bangalore (PTH) from July 2015 and Sankalp-CIMS Centre for Paediatric BMT, Ahmedabad (CIMS) from March 2017. BMTPlus brings together all aspects of transplant data management including clinical data management, personal records and QMS. The usage of these tools which directly relate to the continued quality improvement process was reviewed. Clinical outcomes for patients who underwent transplant for thalassemia in these centres from matched related donors were summarised using R statistical package (version 3.5.x) as an indicator of the effectiveness of the continued quality improvement process. Results: Table 1 summarises the program information, utilisation of various quality management-related records, staff turnover, outcomes and costs. Information technology-driven QMS provided the unique advantage of being able to audit all the data instead of sample data sets and thus widening the potential to detect issues. The inventory management and prescriptions system was audited in 2019 at PTH and the findings are that there were only 3 events in 4 years where important drugs/supplies came close to a critical shortage. Automated treatment plan imports contributed to 2 of the 1570 drug orders being detected with inaccuracies (0.13%). The PTH BMT service has been using BMTPlus for auto submission of data to CIBMTR; data audit in July 2019 showed that 92% of the 1263 due forms were successfully submitted. CIMS is catching up with 39% forms submitted so far. The impact of this quality improvement system on clinical outcomes of the program was measured on 172 successive first matched related transplants (103 from PTH and 69 from CIMS) upto April 15 2019. Outcomes were compared across 3 successive transplant protocols, all patients were transplanted at-least 100 days prior to this analysis. Both overall and disease-free survival improved significantly from protocol 1 to 3, i.e. from 88% to 100% (p = 0.002) and from 77% to 98% (p 〈 0.0001) respectively. Transplant-related mortality and rejection significantly dropped from 10% to 0% (p = 0.01) and from 22% to 3% (p 〈 0.0001) respectively. The outcomes achieved at this lower-middle income centre compared favourably with the 96.9% day-100 survival reported in USA for thalassemia ("U.S. Patient Survival Report" 2017). Progressively improved outcomes and good utilisation of quality management features were seen in spite of the fact that PTH had an attrition rate as high as 44% for physicians and 78% for nurses while in CIMS this was 74% and 57% respectively. The impact of quality management on the cost and sustainability of the program can be seen from the cost of the transplants. Though the programs experienced a 10% increase in operational costs on a year on year basis, the ongoing quality improvements led to fewer complications and cost escalations as a result of which the program at PTH and CIMS continue to offer matched-related transplants at USD 12.500 and USD 13.300 respectively which was the bundled cost set at the beginning of the programs in July-2015 and March-2017 respectively. Thanks to the use of online platform, only one quality/data manager is the only additional resource specific to continued quality improvement, quality assurance, outcome reporting and participation in international registries. Conclusion: Information and communication technology enabled comprehensive knowledge management and facilitated continuous quality improvement. This contributed to the delivery of cost-efficient and effective transplantations with progressively improving outcomes, which finally are at par with the best centres in the world in spite of the challenges of high staff turnover. Disclosures No relevant conflicts of interest to declare.

Print ISSN: 0006-4971

Digitale ISSN: 1528-0020

Thema: Biologie , Medizin

Publiziert von American Society of Hematology

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