Publication Date:
2016-05-20
Description:
Article ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBP ɛ , which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production. Nature Communications doi: 10.1038/ncomms11716 Authors: Hongming Miao, Juanjuan Ou, Yuan Peng, Xuan Zhang, Yujuan Chen, Lijun Hao, Ganfeng Xie, Zhe Wang, Xueli Pang, Zhihua Ruan, Jianjun Li, Liqing Yu, Bingzhong Xue, Hang Shi, Chunmeng Shi, Houjie Liang
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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