ISSN:
1432-1041
Keywords:
cimetidine
;
debrisoquine
;
drug interactions
;
extensive metabolizers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have studied the effect of cimetidine (800 mg·day−1) administration for three days on debrisoquine 4-hydroxylation in nine healthy extensive metabolizers. The debrisoquine metabolic ratio was significantly increased (p〈0.01), but the new ratios remained in the extensive metabolizer range (〈12.6). These data suggest that pre-treatment with cimetidine in usual therapeutic doses will impair debrisoquine 4-hydroxylation, but not enough to alter the apparent oxidation phenotype.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558167
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