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  • 1
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    In silico mapping of complex disease-related traits in mice (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-06-09
    Description: Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months down to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grupe, A -- Germer, S -- Usuka, J -- Aud, D -- Belknap, J K -- Klein, R F -- Ahluwalia, M K -- Higuchi, R -- Peltz, G -- 1 R01 HG02322-01/HG/NHGRI NIH HHS/ -- R01 AR044659/AR/NIAMS NIH HHS/ -- R01 AR044659-07/AR/NIAMS NIH HHS/ -- T32HG-00044/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2001 Jun 8;292(5523):1915-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Genomics, Roche Bioscience, Palo Alto, CA 94303, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11397946" target="_blank"〉PubMed〈/a〉
    Keywords: *Algorithms ; Animals ; Bone Density ; Chromosome Mapping/*methods ; Crosses, Genetic ; Databases, Factual ; *Disease Models, Animal ; Female ; Genetic Linkage ; Genotype ; Humans ; Linkage Disequilibrium ; Major Histocompatibility Complex/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Phenotype ; Polymerase Chain Reaction ; *Polymorphism, Single Nucleotide ; *Quantitative Trait, Heritable ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Regulation of bone mass in mice by the lipoxygenase gene Alox15 (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-01-13
    Description: The development of osteoporosis involves the interaction of multiple environmental and genetic factors. Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice. Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, Robert F -- Allard, John -- Avnur, Zafrira -- Nikolcheva, Tania -- Rotstein, David -- Carlos, Amy S -- Shea, Marie -- Waters, Ruth V -- Belknap, John K -- Peltz, Gary -- Orwoll, Eric S -- AR44659/AR/NIAMS NIH HHS/ -- HG02322/HG/NHGRI NIH HHS/ -- R01 AR044659/AR/NIAMS NIH HHS/ -- R01 AR044659-08/AR/NIAMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jan 9;303(5655):229-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bone and Mineral Research Unit, Department of Medicine, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA. kleinro@ohsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14716014" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonate 12-Lipoxygenase/*genetics/*metabolism ; Arachidonate 15-Lipoxygenase/*genetics/*metabolism ; Bone Density/drug effects/*genetics ; Bone Marrow Cells/metabolism ; Cell Differentiation ; Cells, Cultured ; Crosses, Genetic ; Enzyme Inhibitors/pharmacology ; Female ; Fluorenes/pharmacology ; Gene Expression Profiling ; Genetic Linkage ; Kidney/metabolism ; Lipoxygenase Inhibitors ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Knockout ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; Osteoblasts/cytology/metabolism/physiology ; Osteogenesis ; Osteoporosis/enzymology ; Polymorphism, Genetic ; Quantitative Trait Loci ; Rats ; Receptors, Cytoplasmic and Nuclear/metabolism ; Stromal Cells/metabolism ; Transcription Factors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The D2 receptor gene (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-10-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crabbe, J C -- Belknap, J K -- Buck, K J -- New York, N.Y. -- Science. 1994 Oct 21;266(5184):352-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7939673" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/genetics ; Animals ; Chromosome Mapping ; Mice ; Receptors, Dopamine D2/*genetics/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Genetic animal models of alcohol and drug abuse (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-06-17
    Description: Behavioral and pharmacological responses of selectively bred and inbred rodent lines have been analyzed to elucidate many features of drug sensitivity and the adverse effects of drugs, the underlying mechanisms of drug tolerance and dependence, and the motivational states underlying drug reward and aversion. Genetic mapping of quantitative trait loci (QTLs) has been used to identify provisional chromosomal locations of genes influencing such pharmacological responses. Recent advances in transgenic technology, representational difference analysis, and other molecular methods now make feasible the positional cloning of QTLs that influence sensitivity to drugs of abuse. This marks a new period of synthesis in pharmacogenetic research, in which networks of drug-related behaviors, their underlying pharmacological, physiological, and biochemical mechanisms, and particular genomic regions of interest are being identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crabbe, J C -- Belknap, J K -- Buck, K J -- AA06243/AA/NIAAA NIH HHS/ -- AA08621/AA/NIAAA NIH HHS/ -- DA05228/DA/NIDA NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1994 Jun 17;264(5166):1715-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Service, Veterans Administration (VA) Medical Center, Portland, OR 97201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8209252" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*genetics ; Animals ; Animals, Genetically Modified ; Chromosome Mapping ; *Disease Models, Animal ; Ethanol/pharmacology ; Genetic Techniques ; Mice ; Mice, Inbred Strains ; Oligonucleotides, Antisense/pharmacology ; Rats ; Rats, Inbred Strains ; Reward ; Substance-Related Disorders/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic Commonalities between Ethanol-Induced LORR (Loss of Righting Reflex) and LORR due to Nitrous Oxide, Argon and Nitrogen (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 625 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb33890.x
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  • 6
    Electronic Resource
    Electronic Resource
    Chromosome Mapping of Gene Loci Affecting Morphine and Amphetamine Responses in BXD Recombinant Inbred Mice (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 654 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb25977.x
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  • 7
    Electronic Resource
    Electronic Resource
    Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: Some methodological implications for RI strain analysis (1992)
    Springer
    Behavior genetics 22 (1992), S. 81-100 
    Details
    ISSN: 1573-3297
    Keywords: BXD recombinant inbred strains ; C57BL/6J ; DBA/2J ; saccharin preference ; quantitative trait loci (QTL)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Thesac locus, with a major effect on saccharin preference, was discovered by Fuller (1974) in C57BL/6J (B6), DBA/2J (D2), and derived crosses, and is now supported in the BXD/Ty recombinant inbred (RI) series by a marked bimodal distribution in saccharin preference among 20 strains. The B6 allele led to increased saccharin preference compared to the D2 allele. Since the search for bimodal distributions reflecting major gene loci is an essential part of RI strain analysis, a new statistical method is proposed to test for bimodality, and comparisons are made to previously proposed methods. Another new RI method, quantitative trait loci (QTL) analysis, allows provisional detection and mapping of minor as well as major gene loci. Using this method as a screen, significant associations with saccharin preference were suggested with marker loci on portions of six chromosomes. One of these, theD12nyu1 locus on chromosome 12, was independently supported in a panel of standard (non-RI) inbred strains also tested for saccharin preference. It is unclear whether this reflects thesac locus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066794
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  • 8
    Electronic Resource
    Electronic Resource
    Empirical estimates of bonferroni corrections for use in chromosome mapping studies with the BXD recombinant inbred strains (1992)
    Springer
    Behavior genetics 22 (1992), S. 677-684 
    Details
    ISSN: 1573-3297
    Keywords: BXD recombinant inbred strains ; chromosome mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Most chromosome mapping efforts with the BXD recombinant inbred (RI) strains involve comparisons between a trait of interest and each of a large number of marker loci for evidence of linkage. Such multiple tests or comparisons greatly increase the Type I error rate compared to the single-test situation. Perhaps the most direct way to obtain multiple-test error rates is to employ a Bonferroni correction, where the single-test alpha is multiplied by the number of independent (nonredundant) comparisons (k) to yield a multiple-test alpha that protects against even one fortuitous association with any of the markers. Several empirical estimates ofk are discussed for the published BXD marker set of 142 mapped loci and the newer unpublished marker set (October 1991) comprised of 352 marker loci. Reasonable estimates ofk appear to be roughly 40 and 65 for these two marker sets, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066638
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  • 9
    Electronic Resource
    Electronic Resource
    Quantitative trait loci associated with the behavioral response of B×D recombinant inbred mice to restraint stress: A preliminary communication (1995)
    Springer
    Behavior genetics 25 (1995), S. 489-495 
    Details
    ISSN: 1573-3297
    Keywords: Restraint stress ; recombinant inbred mice ; quantitative trait loci ; affective disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Quantitative trait loci (QTL) analysis was used to make provisional identification of loci containing genes influencing vulnerability to stress. The effect of restraint stress on openfield activity was measured in C57BL/6J and DBA/2J inbred strains of mice and in 22 B×D recombinant inbred strains of mice. QTL analyses were performed by correlating the behavioral delta scores for each group with the strain distribution pattern of 1300 markers for the B×D mice. A significant association was found between postrestraint rearings during min 5 through 8 in the open field and theLamb2 marker on chromosome 1 (r=.718,p〈.0001). Significant associations at thep〈.0001 level were also found between baseline open-field rearings of control mice during min 0 through 5 and theZp3, Ache, andMr66-1 markers on chromosome 5, baseline open-field rearings of control mice during min 5 through 8 and thePmv42 marker on chromosome 15, and open-field rearings of experimental mice during min 0 through 5 and theD11Ncvs61 marker on chromosome 11.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253378
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  • 10
    Electronic Resource
    Electronic Resource
    Differential neurosensitivity to three alcohols and phenobarbital in C57BL/6J and DBA/2J mice (1982)
    Springer
    Behavior genetics 12 (1982), S. 309-317 
    Details
    ISSN: 1573-3297
    Keywords: ethanol ; t-butanol ; phenobarbital ; 1,2-propanediol ; C57BL/6 ; DBA/2 ; inbred mice ; blood alcohol concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Neurosensitivity to ethanol, t-butanol, 1,2-propranediol, and phenobarbital was assessed in C57BL/6J and DBA/2J mice by means of the grid test, a measure of drug-induced ambulatory ataxia. In addition, blood and brain alcohol concentrations at the time of regaining the righting reflex were determined for ethanol and t-butanol. C57BL/6J mice were consistently more neurosensitive than DBA/2J mice to all four drugs on these two tests, but no strain difference was seen with regard to alcohol-induced hypothermia. These findings, and others reported in the literature, indicate that the strain differences in neurosensitivity are very much task dependent in that some measures yield no differences while other measures produce large differences between these two strains. Thus, one strain is not uniformly more sensitive to ethanol than the other across all measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01067850
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