ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The REMA method was found to be very suitable for the synthesis of secretin. The procedure was rapid, since on a 0.2 mmol-scale the rate of one amino acid per day could be attained, and yielded an unambiguous product after simple ion-exchange chromatography. REMA-secretin was found to be chemically identical with secretin prepared by fragment condensations and showed a biological activity of 3.4 (2.9-4.3) clinical units/μg, comparable to that of the natural product (4 clinical units/μg). The yield of purified secretin, a heptacosapeptide amide, calculated on the basis of C-terminal residue, amounted to 5%.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19760590415
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