Publication Date:
2017-09-22
Description:
The dynamic flow properties and compaction characteristics of mannitol and mannitol-sodium carbonate mixtures (80/20, 70/30 and 60/40 by mass) were measured using a Freeman FT4 powder rheometer. The results showed that the mixtures containing up to 30% sodium carbonate had better flow properties and improved compaction characteristics when compared with mannitol alone. The mixtures were also analysed using a shear cell, which gave flow functions that varied little between the samples.The study demonstrated the feasibility of combining a more expensive pharmaceutical excipient with a cheaper ingredient, without compromising desired powder characteristics. It may also provide a useful method for assessing the suitability of new formulations for use as direct compression bases, as part of a wider range of powder flow tests.
Print ISSN:
0930-7516
Electronic ISSN:
1521-4125
Topics:
Chemistry and Pharmacology
,
Process Engineering, Biotechnology, Nutrition Technology
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