Publication Date:
1984-04-20
Description:
Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellular fes (feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slamon, D J -- deKernion, J B -- Verma, I M -- Cline, M J -- AM 18058/AM/NIADDK NIH HHS/ -- CA 15619/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 20;224(4646):256-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6538699" target="_blank"〉PubMed〈/a〉
Keywords:
Adenocarcinoma/genetics
;
Breast Neoplasms/genetics
;
Carcinogens/pharmacology
;
Cell Differentiation
;
Cell Division
;
Cell Transformation, Neoplastic
;
Female
;
Gastrointestinal Neoplasms/genetics
;
Gene Amplification
;
Genes, Viral
;
Genital Neoplasms, Female/genetics
;
Humans
;
Kidney Neoplasms/genetics
;
Leukemia/genetics
;
Lymphoma/genetics
;
Methylation
;
Mutation
;
Neoplasms/*genetics
;
Nucleic Acid Hybridization
;
*Oncogenes
;
RNA, Messenger/genetics
;
RNA, Neoplasm/genetics
;
Sarcoma/genetics
;
*Transcription, Genetic
;
Translocation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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