ISSN:
0899-0042
Keywords:
nucleotide analogue
;
antiviral
;
chiral separation
;
complexation
;
ion-pairing
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An acylonucleotide analogue, 1-[3-hydroxy-2-(phosphonyl-methoxy)propyl]cytosine (HPMPC), has shown activity against herpes simplex Type I and Type II viruses. An HPLC separation of the R- and S-enantiomers of HPMPC by ligand exchange using a mobile phase containing phenylalanine as the chiral modifier and copper(II) as the metal ion is reported.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.530020414
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