ISSN:
1573-739X
Keywords:
Administration, epidural
;
Butyl-p-aminobenzoate
;
Drug compounding
;
Particle size
;
Polyethylene glycol 3350
;
Polysorbate 80
;
Quality control
;
Suspensions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The conditions for the preparation of a 10% butyl-p-aminobenzoate suspension for epidural administration were investigated. Pharmaceutically acceptable suspensions are composed of butyl-p-aminobenzoate particles dispersed in a solvent consisting of the surfactant polysorbate 80 added to normal saline in a concentration of 0.25 mg/ml. pH Correction is not necessary. The suspensions are sterilized at 120°C followed by special milling procedures to accomplish acceptable particle size. Butyl-p-aminobenzoate suspensions are stable at 4°C during a period of at least four weeks.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01963878
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