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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 65 (1975), S. 1343-1349 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 65 (1975), S. 1343-1349 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 162 (1989), S. 435-440 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 174 (1991), S. 181-188 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 164 (1989), S. 119-127 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 36 (1984), S. 194-199 
    ISSN: 1432-0827
    Keywords: Benzo(B)Thiophene-2-Carboxylic Acid ; Bone cells ; Calcium ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The purpose of the present study was to investigate the mechanism of action on bone of Benzo(B)Thiophene-2-Carboxylic Acid (BL-5583). BL-5583, at a dose range of 0.01–100 µg/ml, inhibited spontaneous as well as A23187 and PTH-induced bone resorption in tissue culture. This compound also decreased calcium uptake in both osteoclastic and osteoblastic enriched bone cell populations obtained by sequential collagenase digestion of 1–2 day newborn rat calvariae. The decrease occurred after a 5 min. incubation with45Ca and BL-5583. The effective dose range was 0.01–100 µg/ml. No effect on leucine incorporation or lactic acid production by bone cells was observed. BL-5583 also induced a transient decrease in calcium uptake in skin cells isolated from fetal rats by collagenase digestion, suggesting a lack of tissue specificity for this compound. No effect on cyclic AMP in isolated bone cells was observed with the same dose range that produced a calcium effect.
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  • 7
    ISSN: 1573-0581
    Keywords: Cape Mendocino ; earthquake ; hydrophone ; T-waves ; acoustic propagation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The oceanic T-waves of earthquakes associated with the 1992 Cape Mendocino earthquake sequence were recorded and analyzed using fixed hydrophone arrays located throughout the north-east Pacific Ocean. The T-waves of these events were well recorded with high S/N ratios and strong acoustic energy present over a 0–64 Hz bandwidth. The smallest event recorded by the hydrophone arrays from the sequence had a local magnitude of 2.4. The hydrophone records of the three largest shocks in the sequence (ML 6.9, 6.2, 6.5) exhibited both T-waves and lithospheric phases from these events. Low-pass filtering (2 Hz) of the lithospheric phases yielded a clear P-wave arrival for epicentral distances of 〈10°, but no apparent S-wave. A seafloor cable-break was detected immediately after the second M〉6 aftershock, possibly the result of a submarine slide. The direct P-wave hydrophone records from the second large aftershock showed a relatively high-amplitude, high-frequency arrival, consistent with seismic analyses which used this information to infer rupture direction. The rupture direction was toward the location of the cable break, thus rupture directivity possibly played a role in initiating the slide event. Modelling of the T-wave propagation path, using the Parabolic Equation model, produced estimates of the acoustic transmission loss from epicenter to receiver. The transmission loss to the most distant phones is typically 10-20 dB , and can be as large as 50–70 dB for acoustic propagation paths that cross the continental margin. The amount of acoustic energy each earthquake released into the ocean at the seafloor–water interface was estimated applying the transmission loss and instrument response to the recorded T-wave signals. This acoustic source power level was calculated for 41 events with magnitudes over a recorded range of 2.4≤ML≤6.9, with 17 of these events having their seismic moment estimates available through the NEIC. Ground displacement spectra were estimated from the acoustic power spectra and showed no indication of a corner frequency. Thus empirical analyses relating source level to magnitude and seismic moment were necessary to quantitatively derive an earthquake's size from hydrophone records. The results of indicator variable regression analyses suggest that T-wave source level increases linearly with the event's local magnitude and seismic moment. Furthermore, the source power level versus magnitude relationships for oceanic and continental earthquakes are significantly different, probably illustrating differences in the seismic and acoustic propagation paths from hypocenter to the hydrophone receivers. The results indicate that acoustic measurements provide a reasonable estimate of magnitude and seismic moment of an oceanic earthquake that was not detected by land-based seismic networks.
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  • 8
    ISSN: 1432-0827
    Keywords: Tissue plasminogen activator ; Osteoblasts ; Interleukin-1 ; Tumor necrosis factor β ; Forskolin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The effects of interleukin-1 (IL-1), forskolin, and tumor necrosis factor β (TNF-β) on tissue plasminogen activator (t-PA) activity were studied in the human osteoblastic osteosarcoma cell line, G292. t-PA activity was measured in the cell media using the chromogenic substrate, S-2251. After a 24 hour incubation period, IL-1 increased t-PA in a dose-dependent manner. The effect of IL-1 at 10.0 U/ml was partially inhibited in the presence of indomethacin. Forskolin (1.0 μM) increased t-PA activity after 24 hours with the effects of combined treatment of IL-1 (1.0 U/ml, 10.0 U/ml) and forskolin being apparently additive in nature. TNF-β (10-8–10-7 M) also produced increased t-PA activity in the cell medial after a 24 hour incubation period. These results suggest that the cytokines, IL-1 and TNF-β, can increase t-PA activity in G292 cells and that there is both a cAMP-dependent as well as a cAMP-independent pathway involved in the regulation of this osteoblastic cell function.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 55 (1994), S. 128-133 
    ISSN: 1432-0827
    Keywords: Osteoblast ; Plasma membrane ; Calcium ; Ion channel ; Cell proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Patch clamp physiological techniques were used to characterize the voltage-activated calcium currents (VACC) expressed in the plasma membrane of osteoblastic cells as a function of time in culture and proliferative state of the cell. Osteoblast-enriched preparations were isolated by collagenase digestions of newborn rat calvaria and cultured under different conditions which affected cell proliferation (i.e., low serum in the media to arrest proliferation). VACC were isolated by replacing the intracellular potassium with cesium, and adding 1 μM tetrodotoxin to the bath. Under conditions that favored cell proliferation, low cell density, and media supplemented with 10% fetal calf serum (FCS), a transient calcium current was not expressed until day 3 in culture. There was a statistically significant relationship between the precentage of cells expressing this current and the time in culture. The magnitude of the current significantly increased as days in culture increased. Under the same conditions, the sustained VACC was detected after 7 or 8 days in culture. However, arresting cell proliferation after 2 days in culture by reducing the FCS concentration to 0.01% induced the expression of the sustained VACC the next day. The data suggest that the expression of VACC in the plasma membrane of rat calvarial osteoblasts depends on the time in culture and the state of proliferation of the cells. These results should prove to be valuable in studying the functional significance of VACC in osteoblastic cells and their regulation by various bone regulatory agents.
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  • 10
    ISSN: 1432-0827
    Keywords: Bone cells ; Cyclic AMP ; Calcium ; Ascites fluid resorptive protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The effects of a bone resorptive protein isolated from human cancer ascites fluid on bone cell calcium and cyclic AMP were studied with fetal rat cells. The osteoclast-activating factor increased bone cell calcium uptake at 37°C and 4°C with no direct effects on calcium efflux. Concentrations of the resorptive factor that increased in vitro bone resorption and cell calcium uptake had no effect on cyclic AMP. The effects of the protein on calcium uptake were not specific for bone cells, and large increases were also observed in isolated fetal rat skin cells. These studies suggest that increases in the permeability of the cell membrane to calcium are involved in the mechanism of action of the ascites fluid resorptive protein.
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