Publication Date:
2015-11-11
Description:
Article Age is the greatest risk factor for Alzheimer’s disease, yet how ageing regulates disease pathology is unclear. Here, the authors find that asparagine endopeptidase expression increases with age and cleaves APP, contributing to ß-amyloid production and cognitive defects in a transgenic mouse model. Nature Communications doi: 10.1038/ncomms9762 Authors: Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Duc M. Duong, Nicholas T. Seyfried, Xuebing Cao, Liming Cheng, Yi E. Sun, Shan Ping Yu, Jianping Jia, Allan I. Levey, Keqiang Ye
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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