Publication Date:
2006-11-21
Description:
We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked genetic variants involved in one-carbon metabolism to NHL. We investigated 30 polymorphisms in 18 genes for their main effect on NHL among 1141 incident cases and 949 population-based controls and examined gene-nutrient interactions in a subgroup of 386 cases and 319 controls who provided detailed food-frequency information. Odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for age, sex, and race. We observed a decreased risk of NHL overall with BHMT Ex8+453A〉T and increased risk with CBS Ex13+41C〉T, FPGS Ex15-263T〉C, and SHMT1 Ex12+138C〉T and Ex12+236C〉T. Furthermore, significant gene-nutrient interactions limited the protective association comparing high versus low vitamin B6 to FPGS Ex15-263T〉C CC (OR = 0.22; 95% CI = 0.10-0.52), MTHFS IVS2-1411T〉G TT/TG (OR = 0.54; 95% CI = 0.36-0.81), and MTR Ex26-20A〉G AA (OR = 0.55; 95% CI = 0.35-0.86) genotypes, and the protective association of methionine to FTHFD Ex10-40G〉T GG (OR = 0.63; 95% CI = 0.44-0.91), MTHFR Ex8-62A〉C CC (OR = 0.13; 95% CI = 0.04-0.39), and MTRR Ex5+136T〉C TT (OR = 0.67; 95% CI = 0.47-0.97) genotypes. Warranting replication, our finding of gene-nutrient interactions in one-carbon metabolism supports their etiologic involvement in lymphomagenesis.
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
Permalink