Publication Date:
2016-06-18
Description:
Chemical examination of a marine sponge Xestospongia sp. resulted in the isolation of 20 sterol derivatives ( 1 - 20 ), including eight new sterols namely aragusterols J-L ( 1-3 ), (5 α ,7 α ,12 β ,22 E )-7,12,18-trihydroxystigmast-22-en-3-one ( 4 ), (5 α ,7 α ,12 β ,24 R )- and (5 α ,7 α ,12 β ,24 S )-7,12,20-trihydroxystigmastan-3-one ( 5 / 6 ), and (5 α ,7 α ,12 β ,22 E ,24 R )- and (5 α ,7 α ,12 β ,22 E ,24 S )-7,12,20-trihydroxyergost-22-en-3-one ( 7 / 8 ). The structures of new compounds were determined through extensive spectroscopic analyses and chemical conversion. The sterol diversity was mainly characterized by the presence of a cyclopropane unit at side chain, while compound 4 with 18-hydroxymethyl group was found in stigmasterol family for the first time. Cytotoxic test revealed the inhibitory effects of compounds 1 , 4 , and 17 against human leukemia cell line K562 with IC 50 values of 18.3, 24.1, and 34.3 μ M, respectively. This article is protected by copyright. All rights reserved.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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