Publication Date:
1988-11-04
Description:
Mechanosensitive ion channels use mechanical energy to gate the dissipation of electrochemical gradients across cell membranes. This function is fundamental to physiological processes such as hearing and touch. In electrophysiological studies of ion channels in the plasma membrane of the yeast Saccharomyces cerevisiae, channels were observed that were activated by, and adapted to, stretching of the membrane. Adaptation of channel activity to mechanical stimuli was voltage-dependent. Because these mechanosensitive channels pass both cations and anions, they may play a role in turgor regulation in this walled organism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gustin, M C -- Zhou, X L -- Martinac, B -- Kung, C -- GM37925/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1988 Nov 4;242(4879):762-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Biology, University of Wisconsin, Madison 53706.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2460920" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological
;
Anions/physiology
;
Cations/physiology
;
Cell Membrane/*physiology
;
Cell Membrane Permeability
;
Hydrostatic Pressure
;
Ion Channels/*physiology
;
Membrane Potentials
;
Saccharomyces cerevisiae/*physiology
;
Surface Tension
;
Water-Electrolyte Balance
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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