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  • Other Sources  (983)
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  • 1
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    Hypersonic Inflatable Aerodynamic Decelerator (HIAD) Technology Development Overview (2013)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The successful flight of the Inflatable Reentry Vehicle Experiment (IRVE)-3 has further demonstrated the potential value of Hypersonic Inflatable Aerodynamic Decelerator (HIAD) technology. This technology development effort is funded by NASA's Space Technology Mission Directorate (STMD) Game Changing Development Program (GCDP). This paper provides an overview of a multi-year HIAD technology development effort, detailing the projects completed to date and the additional testing planned for the future.
    Keywords: Spacecraft Design, Testing and Performance
    Type: NF1676L-16795 , International Planetary Probe Workshop (IPPW-10); Jun 17, 2013 - Jun 21, 2013; San Jose, CA; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 2
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    Very High Energy Outburst of Markarian 501 in May 2009 (2016)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The very high energy (VHE; E great than 100 GeV) blazar Markarian 501 was observed between April 17 and May 5 (MJD 5493854956), 2009, as part of an extensive multi-wavelength campaign from radio to VHE. Strong VHE -ray activity was detected on May 1st with Whipple and VERITAS, when the flux (E greater than 400 GeV) increased to 10 times the pre-flare baseline flux (3.9 x 10(exp -11 ph cm(exp -2 S(exp -1), reaching five times the flux of the Crab Nebula. This coincided with a decrease in the optical polarization and a rotation of the polarization angle by 15deg. This VHE flare showed a fast flux variation with an increase of a factor approximately 4 in 25 min, and a falling time of approximately 50 min. We present the observations of the quiescent state previous to the flare and of the high state after the flare, focusing on the flux and spectral variability from Whipple, VERITAS, Fermi-LAT, RXTE, and Swift combined with optical and radio data.
    Keywords: Astrophysics
    Type: GSFC-E-DAA-TN44061 , Astronomy & Astrophysics (ISSN 0004-6361) (e-ISSN 1432-0746); 594; A76
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    NASA TECHNICAL REPORTS
  • 3
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    The observed recent surface air temperature development across Svalbard and concurring footprints in local sea ice cover (2021)
    Details
    Publication Date: 2021-10-12
    Description: The Svalbard archipelago in the Arctic North Atlantic is experiencing rapid changes in the surface climate and sea ice distribution, with impacts for the coupled climate system and the local society. This study utilizes observational data of surface air temperature (SAT) from 1980–2016 across the whole Svalbard archipelago, and sea ice extent (SIE) from operational sea ice charts to conduct a systematic assessment of climatologies, long-term changes and regional differences. The proximity to the warm water mass of the West Spitsbergen Current drives a markedly warmer climate in the western coastal regions compared to northern and eastern Svalbard. This imprints on the SIE climatology in southern and western Svalbard, where the annual maxima of 50–60% area ice coverage are substantially less than 80–90% in the northern and eastern fjords. Owing to winter-amplified warming, the local climate is shifting towards more maritime conditions, and SIE reductions of between 5 and 20% per decade in particular regions are found, such that a number of fjords in the west have been virtually ice-free in recent winters. The strongest decline comes along with SAT forcing and occurs over the most recent 1–2 decades in all regions; while in the 1980s and 1990s, enhanced northerly winds and sea ice drift can explain 30–50% of SIE variability around northern Svalbard, where they had correspondingly lead to a SIE increase. With an ongoing warming it is suggested that both the meteorological and cryospheric conditions in eastern Svalbard will become increasingly similar to what is already observed in the western fjords, namely suppressed typical Arctic climate conditions.
    Keywords: 551.6 ; Arctic warming ; climatology ; observations ; sea ice ; surface meteorology ; Svalbard
    Language: English
    Type: map
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    CITATION GEO-LEO
  • 4
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    Velocity filtering of seismic reflection data (1983)
    In:  First Break, Taipei, Elsevier, vol. 1, no. 7-8, pp. 9-24, pp. RG2001, (ISBN: 0-12-018847-3)
    Details
    Publication Date: 1983
    Keywords: Reflection seismics ; Filter- ; Velocity analysis ; Seismics (controlled source seismology)
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    BIBLIOGRAPHY SEISMOLOGY
  • 5
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    A confirmed earthquake in continental Antarctica (1985)
    In:  Geophys. J. R. astr. Soc., Dordrecht, D. Reidel, vol. 81, no. 6, pp. 489-492
    Details
    Publication Date: 1985
    Keywords: Earthquake ; Seismicity ; GJRaS
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    BIBLIOGRAPHY SEISMOLOGY
  • 6
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    Water-level changes induced by local and distant earthquakes at Long Valley Caldera, California (2003)
    In:  Journal of Volcanology and Geothermal Research, Oslo, Wiley, vol. 127, no. 3-4, pp. 269-203, pp. B08303, (ISSN: 1340-4202)
    Details
    Publication Date: 2003
    Keywords: Volcanology ; Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Seismicity ; Fluids ; poro-elasticity ; USA ; JVGR
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    BIBLIOGRAPHY SEISMOLOGY
  • 7
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    Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication (1992)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: We have investigated the direct effect of dimethyl prostaglandin A1 (dmPGA1) on the replication of herpes simplex virus (HSV) and human immunodeficiency virus type 1 (HIV-1). dmPGA1 significantly inhibited viral replication in both HSV and HIV infection systems at concentrations of dmPGA1 that did not adversely alter cellular DNA synthesis. The 50% inhibitory concentration (ID50) for several HSV type 1 (HSV-1) strains ranged from 3.8 to 5.6 micrograms/ml for Vero cells and from 4.6 to 7.3 micrograms/ml for human foreskin fibroblasts. The ID50s for two HSV-2 strains varied from 3.8 to 4.5 micrograms/ml for Vero cells; the ID50 was 5.7 micrograms/ml for human foreskin fibroblasts. We found that closely related prostaglandins did not have the same effect on the replication of HSV; dmPGE2 and dmPGA2 caused up to a 60% increase in HSV replication compared with that in untreated virus-infected cells. HIV-1 replication in acutely infected T cells (VB line) and chronically infected macrophages was assessed by quantitative decreases in p24 concentration. The effective ID50s were 2.5 micrograms/ml for VB cells acutely infected with HIV-1 and 5.2 micrograms/m for chronically infected macrophages. dmPGA1 has an unusual broad-spectrum antiviral activity against both HSV and HIV-1 in vitro and offers a new class of potential therapeutic agents for in vivo use.
    Keywords: Life Sciences (General)
    Type: Antimicrobial agents and chemotherapy (ISSN 0066-4804); Volume 36; 10; 2253-8
    Format: text
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  • 8
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    Review of the biological effects of weightlessness on the human endocrine system (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Studies from space flights over the past two decades have demonstrated that there are basic physiological changes in humans during space flight. These changes include cephalad fluid shifts, loss of fluid and electrolytes, loss of muscle mass, space motion sickness, anemia, reduced immune response, and loss of calcium and mineralized bone. The cause of most of these manifestations is not known but the general approach has been to investigate systemic and hormonal changes. However, data from the 1973-1974 Skylabs, Spacelab 3 (SL-3), Spacelab D-I (SL-DI), and now the new SLS-1 missions support a more basic biological response to microgravity that may occur at the tissue, cellular, and molecular level. This report summarizes ground-based and SLS-1 experiments that examined the mechanism of loss of red blood cell mass in humans, the loss of bone mass and lowered osteoblast growth under space flight conditions, and loss of immune function in microgravity.
    Keywords: Life Sciences (General)
    Type: Receptor (ISSN 1052-8040); Volume 3; 3; 145-54
    Format: text
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  • 9
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    Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies (1999)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Many colorectal cancers have high levels of cyclo-oxygenase 2 (COX-2), an enzyme that metabolizes the essential fatty acids into prostaglandins. Since the low-density lipoprotein receptor (LDLr) is involved in the uptake of essential fatty acids, we studied the effect of LDL on growth and gene regulation in colorectal cancer cells. DiFi cells grown in lipoprotein-deficient sera (LPDS) grew more slowly than cells with LDL. LDLr antibody caused significant inhibition of tumor cell growth but did not affect controls. In addition, LDL uptake did not change in the presence of excess LDL, suggesting that ldlr mRNA lacks normal feedback regulation in some colorectal cancers. Analysis of the ldlr mRNA showed that excess LDL in the medium did not cause down-regulation of the message even after 24 hr. The second portion of the study examined the mRNA expression of ldlr and its co-regulation with cox-2 in normal and tumor specimens from patients with colorectal adenocarcinomas. The ratio of tumor:paired normal mucosa of mRNA expression of ldlr and of cox-2 was measured in specimens taken during colonoscopy. ldlr and cox-2 transcripts were apparent in 11 of 11 carcinomas. There was significant coordinate up-regulation both of ldlr and of cox-2 in 6 of 11 (55%) tumors compared with normal colonic mucosa. There was no up-regulation of cox-2 without concomitant up-regulation of ldlr. These data suggest that the LDLr is abnormally regulated in some colorectal tumors and may play a role in the up-regulation of cox-2. Copyright 1999 Wiley-Liss, Inc.
    Keywords: Life Sciences (General)
    Type: International journal of cancer. Journal international du cancer (ISSN 0020-7136); Volume 83; 2; 162-6
    Format: text
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    NASA TECHNICAL REPORTS
  • 10
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    Prostaglandin E2 and the protein kinase A pathway mediate arachidonic acid induction of c-fos in human prostate cancer cells (2000)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: Arachidonic acid (AA) is the precursor for prostaglandin E2 (PGE2) synthesis and increases growth of prostate cancer cells. To further elucidate the mechanisms involved in AA-induced prostate cell growth, induction of c-fos expression by AA was investigated in a human prostate cancer cell line, PC-3. c-fos mRNA was induced shortly after addition of AA, along with a remarkable increase in PGE2 production. c-fos expression and PGE2 production induced by AA was blocked by a cyclo-oxygenase inhibitor, flurbiprofen, suggesting that PGE2 mediated c-fos induction. Protein kinase A (PKA) inhibitor H-89 abolished induction of c-fos expression by AA, and partially inhibited PGE2 production. Protein kinase C (PKC) inhibitor GF109203X had no significant effect on c-fos expression or PGE2 production. Expression of prostaglandin (EP) receptors, which mediate signal transduction from PGE2 to the cells, was examined by reverse transcription polymerase chain reaction in several human prostate cell lines. EP4 and EP2, which are coupled to the PKA signalling pathway, were expressed in all cells tested. Expression of EP1, which activates the PKC pathway, was not detected. The current study showed that induction of the immediate early gene c-fos by AA is mediated by PGE2, which activates the PKA pathway via the EP2/4 receptor in the PC-3 cells.
    Keywords: Life Sciences (General)
    Type: British journal of cancer (ISSN 0007-0920); Volume 82; 12; 2000-6
    Format: text
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