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  • Articles  (71)
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  • 1
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    In situ visualization of a glycoform of transferrin: localization of {alpha}2,6-sialylated transferrin in the liver (2015)
    Oxford University Press
    Details
    Publication Date: 2015-03-28
    Description: We previously found that a lectin, Sambucus sieboldiana agglutinin (SSA), bound to α2,6-sialylated glycan epitopes on transferrin and inhibited anti-transferrin antibody binding to the antigen in ELISA (SSA inhibition). Here we report that SSA inhibition is applicable to immunohistochemistry, localizing α2,6-sialylated transferrin in the liver. Immunohistochemistry using anti-transferrin polyclonal antibody revealed that transferrin was detected in hepatocytes near interlobular veins. Addition of SSA lectin markedly attenuated the staining. Sialidase treatment of a liver section abolished SSA binding and concomitantly cancelled SSA inhibition, suggesting that SSA binding to glycan epitopes on the section was essential for the inhibition. To examine the importance of proximity between antigen epitopes and SSA-binding (glycosylation) sites, we prepared two anti-peptide antibodies against partial amino acid sequences of transferrin. One antibody (Tf-596Ab) is against a peptide sequence, Cys596-Ala614, which is proximal to N -glycosylation sites (Asn-432 and Asn-630). The other (Tf-120Ab) is against a peptide sequence, Val120-Cys137, distal to the sites. The staining signals of Tf-596Ab were reduced by the addition of SSA, whereas those of Tf-120Ab were reduced only a little. This result suggests that proximity of the antigen epitope to SSA binding sites is critical for SSA inhibition in immunohistochemistry.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
    Published by Oxford University Press on behalf of The Japanese Biochemical Society (JBS).
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  • 2
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    Plant Raf-like kinase for ABA and stress signaling [Plant Biology] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-11-18
    Description: Plant response to drought and hyperosmosis is mediated by the phytohormone abscisic acid (ABA), a sesquiterpene compound widely distributed in various embryophyte groups. Exogenous ABA as well as hyperosmosis activates the sucrose nonfermenting 1 (SNF1)-related protein kinase2 (SnRK2), which plays a central role in cellular responses against drought and dehydration,...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    An origin of the radio jet in M87 at the location of the central black hole (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-09-09
    Description: Powerful radio jets from active galactic nuclei are thought to be powered by the accretion of material onto the supermassive black hole (the 'central engine'). M87 is one of the closest examples of this phenomenon, and the structure of its jet has been probed on a scale of about 100 Schwarzschild radii (R(s), the radius of the event horizon). However, the location of the central black hole relative to the jet base (a bright compact radio 'core') remains elusive. Observations of other jets indicate that the central engines are located about 10(4)-10(6)R(s) upstream from the radio core. Here we report radio observations of M87 at six frequencies that allow us to achieve a positional accuracy of about 20 microarcseconds. As the jet base becomes more transparent at higher frequencies, the multifrequency position measurements of the radio core enable us to determine the upstream end of the jet. The data reveal that the central engine of M87 is located within 14-23R(s) of the radio core at 43 GHz. This implies that the site of material infall onto the black hole and the eventual origin of the jet reside in the bright compact region seen on the image at 43 GHz.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hada, Kazuhiro -- Doi, Akihiro -- Kino, Motoki -- Nagai, Hiroshi -- Hagiwara, Yoshiaki -- Kawaguchi, Noriyuki -- England -- Nature. 2011 Sep 7;477(7363):185-7. doi: 10.1038/nature10387.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomical Science, The Graduate University for Advanced Studies (SOKENDAI), 2-21-1 Osawa, Mitaka, Tokyo 181-8588, Japan. kazuhiro.hada@nao.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21901008" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-11-03
    Description: Severe childhood autosomal recessive muscular dystrophy (SCARMD) is a progressive muscle-wasting disorder common in North Africa that segregates with microsatellite markers at chromosome 13q12. Here, it is shown that a mutation in the gene encoding the 35-kilodalton dystrophin-associated glycoprotein, gamma-sarcoglycan, is likely to be the primary genetic defect in this disorder. The human gamma-sarcoglycan gene was mapped to chromosome 13q12, and deletions that alter its reading frame were identified in three families and one of four sporadic cases of SCARMD. These mutations not only affect gamma-sarcoglycan but also disrupt the integrity of the entire sarcoglycan complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, S -- McNally, E M -- Ben Othmane, K -- Hagiwara, Y -- Mizuno, Y -- Yoshida, M -- Yamamoto, H -- Bonnemann, C G -- Gussoni, E -- Denton, P H -- Kyriakides, T -- Middleton, L -- Hentati, F -- Ben Hamida, M -- Nonaka, I -- Vance, J M -- Kunkel, L M -- Ozawa, E -- NS23740/NS/NINDS NIH HHS/ -- P01-NS26630/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 3;270(5237):819-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Neuroscience, National Center for Neurology and Psychiatry, Tokyo, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481775" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; *Chromosomes, Human, Pair 13 ; *Cytoskeletal Proteins ; DNA, Complementary/genetics ; Dystrophin/chemistry/genetics/metabolism ; Humans ; Linkage Disequilibrium ; Membrane Glycoproteins/chemistry/*genetics/metabolism ; Molecular Sequence Data ; Molecular Weight ; Muscle, Skeletal/chemistry/metabolism ; Muscular Dystrophies/*genetics ; Mutation ; Phenotype ; Rabbits ; Sarcoglycans ; Sequence Deletion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans (2013)
    Oxford University Press
    Details
    Publication Date: 2013-04-14
    Description: A large fraction of protein-coding genes in metazoans undergo alternative pre-mRNA splicing in tissue- or cell-type-specific manners. Recent genome-wide approaches have identified many putative-binding sites for some of tissue-specific trans -acting splicing regulators. However, the mechanisms of splicing regulation in vivo remain largely unknown. To elucidate the modes of splicing regulation by the neuron-specific CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans , we performed deep sequencing of poly(A) + RNAs from the unc-75(+)- and unc-75- mutant worms and identified more than 20 cassette and mutually exclusive exons repressed or activated by UNC-75. Motif searches revealed that (G/U)UGUUGUG stretches are enriched in the upstream and downstream introns of the UNC-75-repressed and -activated exons, respectively. Recombinant UNC-75 protein specifically binds to RNA fragments carrying the (G/U)UGUUGUG stretches in vitro . Bi-chromatic fluorescence alternative splicing reporters revealed that the UNC-75-target exons are regulated in tissue-specific and (G/U)UGUUGUG element-dependent manners in vivo . The unc-75 mutation affected the splicing reporter expression specifically in the nervous system. These results indicate that UNC-75 regulates alternative splicing of its target exons in neuron-specific and position-dependent manners through the (G/U)UGUUGUG elements in C. elegans . This study thus reveals the repertoire of target events for the CELF family in the living organism.
    Keywords: RNA characterisation and manipulation
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 6
    Electronic Resource
    Electronic Resource
    Electrical detection of end point in polishing process of thin-film heads (invited) (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 4163-4166 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A novel method for detecting the polishing process end point was developed for thin-film heads to achieve a gap depth (throat height) of smaller than 1.5 μm. Special thin-film heads whose magnetic paths are closed at the front end of the gap films were used. As the throat height of these gap films are much the same as the maximum tolerable value of the gap depth, the end point can be detected by monitoring the opening of the magnetic paths of the thin-film head themselves. Electrical detection of the opening was studied, utilizing the bias current dependence of the head inductance. Both inductance values of the head, with and without the bias current, Lb and Lnb, change when the magnetic path opens. The Lnb and Lb values at 3-mA bias current are 250 and 95 nH for the head having a closed magnetic path, and 180 and 155 nH for an open one, respectively. The difference Lnb−Lb decreases to about 1/6 when the magnetic path is opened. An apparatus was developed to measure the amplitude of Lnb−Lb. It utilizes a Wheatstone bridge circuit, excited with a 10-MHz sinusoidal signal for measuring inductance, and a 0.2-Hz rectangular pulse train as a bias current, respectively. Experimental results indicate that polishing can be stopped within 0.6 μm of the front edge of the gap films.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.338515
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  • 7
    Electronic Resource
    Electronic Resource
    A METHOD FOR ESTIMATING FATIGUE CRACK PROPAGATION IN PRE-STRAINED AND MEAN STRESSED SPECIMENS (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 1 (1979), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A method for quantifying the effect of plane stress, plane strain, mean stress and pre-strain on fatigue crack propagation rates in plates of different thicknesses is proposed. Experimental verification was carried out on mild steel plates of 0·2, 0·4, 0·6, 0·8, 1·0, 1·2 and 1·4 mm thick specimens. The conflicting effects of variations in stress intensity factors along the crack front and changes from plane stress to plane strain conditions along the crack front are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1979.tb01332.x
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  • 8
    Electronic Resource
    Electronic Resource
    Selective Defect of Sarcoglycan Complex in Severe Childhood Autosomal Recessive Muscular Dystrophy Muscle
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 203 (1994), S. 979-983 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1994.2278
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  • 9
    Electronic Resource
    Electronic Resource
    Demonstration of Derivation of Rat Urinary Bradykinin from Plasma Low-Molecular-Weight Kininogen: A Study Using Kininogen-Deficient Rats
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 204 (1994), S. 1219-1224 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1994.2593
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  • 10
    Electronic Resource
    Electronic Resource
    Regulation of urine marking in male and female mice: Effects of sex steroids
    Amsterdam : Elsevier
    Hormones and Behavior 19 (1985), S. 64-70 
    Details
    ISSN: 0018-506X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0018-506X(85)90006-6
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