ISSN:
1432-1041
Keywords:
Insulin action
;
Hypertension
;
whole body glucose disposal
;
skeletal muscle blood flow
;
membrane microviscosity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Fourteen hypertensive (174.3/98.3 mmHg) non-diabetic patients were given a euglyceamic glucose clamp along with infusion of 0.9% NaCl and the prostacyclin (PGI2) analogue Iloporst (0.7 ng · kg · min−1). Substrate oxidation was also determined by indirect calorimetry. Over the last 60 min of the clamp, Iloprost vs saline improved whole body glucose disposal (WBGD) (35 vs 28.3 μmol · kg−1 LBM) and non-oxidative glucose metabolism (24.7 vs 18.1 μmol · kg−1 LBM · min−1). Iloprost delivery was associated with a significant decrease in membrane microviscosity (0.253 vs 0.205), but did not affect arterial blood pressure and heart rate. In nine patients, skeletal muscle blood flow (SMBF) and insulin-stimulated glucose uptake (GU) were also studied. At the end of the study, despite a similar SMBF (37 vs 38 ml · min−1 · kg−1), GU (0.55 vs 0.46 mmol · 1−1) was significantly increased by Iloprost infusion. Percentage decrease in membrane microviscosity was correlated with percentage increase in WBGD (r=0.65) and non-oxidative glucose metabolism (r=0.68). In conclusion, low-dose Iloprost infusion improves insulin action and non-oxidative glucose metabolism in hypertensive patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00194947
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