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  • Articles  (63)
  • Medicine  (63)
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  • Articles  (63)
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  • 1
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    BESC knowledgebase public portal (2012)
    Oxford University Press
    Details
    Publication Date: 2012-03-01
    Description: The BioEnergy Science Center (BESC) is undertaking large experimental campaigns to understand the biosynthesis and biodegradation of biomass and to develop biofuel solutions. BESC is generating large volumes of diverse data, including genome sequences, omics data and assay results. The purpose of the BESC Knowledgebase is to serve as a centralized repository for experimentally generated data and to provide an integrated, interactive and user-friendly analysis framework. The Portal makes available tools for visualization, integration and analysis of data either produced by BESC or obtained from external resources. Availability: http://besckb.ornl.gov Contact: syedmh@ornl.gov
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 2
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    More deafness genes (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steel, K P -- Brown, S D -- New York, N.Y. -- Science. 1998 May 29;280(5368):1403.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council, Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK. karen@ihr.mrc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9634418" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/physiology ; Animals ; Cilia/physiology ; Deafness/*genetics ; Dyneins ; Extracellular Matrix Proteins/*genetics/physiology ; GPI-Linked Proteins ; Hair Cells, Auditory/physiology/ultrastructure ; Hearing ; Humans ; Membrane Glycoproteins/*genetics/physiology ; Mice ; Mice, Mutant Strains ; Mutation ; Myosin Heavy Chains/genetics/physiology ; Myosins/*genetics/physiology ; Tectorial Membrane/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Sequence interpretation. Functional annotation of mouse genome sequences (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nadeau, J H -- Balling, R -- Barsh, G -- Beier, D -- Brown, S D -- Bucan, M -- Camper, S -- Carlson, G -- Copeland, N -- Eppig, J -- Fletcher, C -- Frankel, W N -- Ganten, D -- Goldowitz, D -- Goodnow, C -- Guenet, J L -- Hicks, G -- Hrabe de Angelis, M -- Jackson, I -- Jacob, H J -- Jenkins, N -- Johnson, D -- Justice, M -- Kay, S -- Kingsley, D -- Lehrach, H -- Magnuson, T -- Meisler, M -- Poustka, A -- Rinchik, E M -- Rossant, J -- Russell, L B -- Schimenti, J -- Shiroishi, T -- Skarnes, W C -- Soriano, P -- Stanford, W -- Takahashi, J S -- Wurst, W -- Zimmer, A -- International Mouse Mutagenesis Consortium -- New York, N.Y. -- Science. 2001 Feb 16;291(5507):1251-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, BRB 624, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. jhn4@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11233449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Computational Biology ; Costs and Cost Analysis ; Genes/physiology ; Genetic Techniques ; *Genome ; *Genomics ; International Cooperation ; Mice/*genetics ; Mutagenesis ; Mutation ; Phenotype ; Private Sector ; Public Sector ; Research Support as Topic ; *Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Post-publication sharing of data and tools (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-09-11
    Description: Despite existing guidelines on access to data and bioresources, good practice is not widespread. A meeting of mouse researchers in Rome proposes ways to promote a culture of sharing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schofield, Paul N -- Bubela, Tania -- Weaver, Thomas -- Portilla, Lili -- Brown, Stephen D -- Hancock, John M -- Einhorn, David -- Tocchini-Valentini, Glauco -- Hrabe de Angelis, Martin -- Rosenthal, Nadia -- CASIMIR Rome Meeting participants -- 062023/Wellcome Trust/United Kingdom -- 077198/Wellcome Trust/United Kingdom -- MC_U142684171/Medical Research Council/United Kingdom -- England -- Nature. 2009 Sep 10;461(7261):171-3. doi: 10.1038/461171a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK. PS@mole.bio.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19741686" target="_blank"〉PubMed〈/a〉
    Keywords: *Access to Information ; Animals ; Cell Line ; *Cooperative Behavior ; Guidelines as Topic ; Information Storage and Retrieval ; Licensure ; Mice ; Models, Animal ; *Publishing/standards ; *Research/standards ; Research Design ; Rome ; Technology Transfer
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    The genetic basis for bacterial mercury methylation (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-09
    Description: Methylmercury is a potent neurotoxin produced in natural environments from inorganic mercury by anaerobic bacteria. However, until now the genes and proteins involved have remained unidentified. Here, we report a two-gene cluster, hgcA and hgcB, required for mercury methylation by Desulfovibrio desulfuricans ND132 and Geobacter sulfurreducens PCA. In either bacterium, deletion of hgcA, hgcB, or both genes abolishes mercury methylation. The genes encode a putative corrinoid protein, HgcA, and a 2[4Fe-4S] ferredoxin, HgcB, consistent with roles as a methyl carrier and an electron donor required for corrinoid cofactor reduction, respectively. Among bacteria and archaea with sequenced genomes, gene orthologs are present in confirmed methylators but absent in nonmethylators, suggesting a common mercury methylation pathway in all methylating bacteria and archaea sequenced to date.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parks, Jerry M -- Johs, Alexander -- Podar, Mircea -- Bridou, Romain -- Hurt, Richard A Jr -- Smith, Steven D -- Tomanicek, Stephen J -- Qian, Yun -- Brown, Steven D -- Brandt, Craig C -- Palumbo, Anthony V -- Smith, Jeremy C -- Wall, Judy D -- Elias, Dwayne A -- Liang, Liyuan -- New York, N.Y. -- Science. 2013 Mar 15;339(6125):1332-5. doi: 10.1126/science.1230667. Epub 2013 Feb 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23393089" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Bacterial Proteins/*genetics ; Corrinoids/genetics ; Desulfovibrio desulfuricans/*genetics/metabolism ; Environmental Pollutants/*metabolism ; Ferredoxins/genetics ; Gene Deletion ; Geobacter/*genetics/metabolism ; Mercury/*metabolism ; Methylation ; Molecular Sequence Data ; *Multigene Family
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Helpers: effects of experimental removal on reproductive success (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-22
    Description: Experimental removal of helpers from a communal bird population decreased the reproductive success of the reduced units. By controlling for variables that are potentially correlated with both reproductive success and unit size, this experiment establishes that helpers-contribute significantly to their indirect fitness.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, J L -- Brown, E R -- Brown, S D -- Dow, D D -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):421-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17814957" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Molecular drive (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dover, G A -- Strachan, T -- Coen, E S -- Brown, S D -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1069.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146894" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; DNA/*genetics ; Genes ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
    Electronic Resource
    Electronic Resource
    Construction of a mouse yeast artificial chromosome library in a recombination–deficient strain of yeast (1992)
    [s.l.] : Nature Publishing Group
    Nature genetics 1 (1992), S. 132-136 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We have constructed a new generation yeast artificial chromosome (YAC) library from female C57BL/10 mice in a recombination–deficient strain of Saccharomyces cerevisiae carrying a mutation in the RAD52 gene. The YAC library contains 41,568 clones with an average insert size of 240 kilobases, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0592-132
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    A type VII myosin encoded by the mouse deafness gene shaker-1 (1995)
    [s.l.] : Nature Publishing Group
    Nature 374 (1995), S. 62-64 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Olfactory marker protein gene (Omp) is very tightly linked to the mouse shl mutation on mouse chromosome 7 (ref. 8). In a backcross of 1,066 progeny segregating for the shl mutation, Omp is non-recombinant with shl, indicating that the shl locus is likely to lie within 0.1 centimorgan ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/374062a0
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  • 10
    Electronic Resource
    Electronic Resource
    Conservation of segmental variants of satellite DNA of Mus musculus in a related species: Mus spretus (1980)
    [s.l.] : Nature Publishing Group
    Nature 285 (1980), S. 47-49 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Analytical equilibrium sedimentation in neutral CsCl of total DNA of M. spretus that is bound to the dye Hoechst 33258 does not reveal a satellite DNA component (Fig. 1b) equivalent to that resolved from the total DNA of M. musculus sedimented in the same conditions (Fig. 1a). Hoechst 33258-CsCl ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/285047a0
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